Emergency Department, Numune Training and Research Hospital, Ankara 06370, Turkey.
World J Emerg Surg. 2014 Feb 10;9(1):16. doi: 10.1186/1749-7922-9-16.
Head injury is the main cause of death among individuals younger than 45 years old. Cranial Computerized tomography (CT) is commonly used for diagnosis of head injury. Brain Natriuretic Peptide (BNP) is a peptide originally isolated from brain ventricles. The main aim of this study is to investigate BNP as an indicator of head injury among patients presenting to emergency department (ED) with minor head trauma.
This was a prospective study conducted at the emergency department of the Numune Training and Research Hospital. A total of 162 patients who presented to the ED with minor head injury were enrolled. The patients were categorized into 2 groups as the cranial CT-negative and positive groups. The normality of the data was tested using One Sample Kolmogorov Smirnov test. Mann-Whitney U test was used to compare 2 independent groups while the Kruskal-Wallis test was utilized for comparison of more than 2 groups. A p-value of <0.05 was considered to be significant.
Ninety-six (59.3%) patients were male and 66 (40.7%) were female. The cranial CT-negative group had a median BNP level of 14.5 pg/ml while the cranial CT-positive group had a median BNP level of 13 pg/ml. There was no statistically significant difference between these two groups for serum BNP levels (p > 0.05).
This study suggested that serum BNP level wasn't used in defined of intracranial injury.
头部损伤是 45 岁以下人群死亡的主要原因。颅部计算机断层扫描（CT）常用于头部损伤的诊断。脑利钠肽（BNP）是一种最初从脑室中分离出来的肽。本研究的主要目的是研究 BNP 作为急诊（ED）因轻度头部创伤就诊的患者头部损伤的指标。
这是在努穆恩培训和研究医院急诊科进行的一项前瞻性研究。共纳入 162 名因轻度头部损伤就诊于 ED 的患者。将患者分为颅 CT 阴性和阳性两组。使用单样本 Kolmogorov Smirnov 检验检验数据的正态性。使用 Mann-Whitney U 检验比较 2 个独立组，使用 Kruskal-Wallis 检验比较 2 个以上组。p 值<0.05 被认为具有统计学意义。
96 名（59.3%）患者为男性，66 名（40.7%）为女性。颅 CT 阴性组的 BNP 中位数为 14.5pg/ml，颅 CT 阳性组的 BNP 中位数为 13pg/ml。这两组之间的血清 BNP 水平无统计学差异（p>0.05）。
本研究表明，血清 BNP 水平不能用于定义颅内损伤。
