Schaller J, Haustein U F, Fiebig H
Department of Dermatology, Karl-Marx-University, Leipzig, GDR.
Acta Derm Venereol. 1987;67(6):520-3.
In 10 untreated patients suffering from acute bullous pemphigoid the number of peripheral blood T cells (CD 3), T suppressor (CD 8) and T helper cells (CD 4) as well as activation antigens (DR and Tac) bearing lymphocytes was evaluated by monoclonal antibodies. While the pan-T cell population (CD 3) and T suppressor subpopulation (CD 8) were normal, the T helper subpopulation (CD 4) and the number of DR and Tac positive lymphocytes were significantly increased in the acute stage of bullous pemphigoid when compared to the age- and sex-matched controls. Phenotypically those DR positive cells belonged to the pan-T cell population (CD 3) at 66% and to the T helper subpopulation (CD 4) at 53% respectively. Under treatment with immunosuppressants the cell counts returned to normal suggesting a T helper cell activation to be involved in the acute stage of bullous pemphigoid.
采用单克隆抗体对10例未经治疗的急性大疱性类天疱疮患者外周血中的T细胞（CD3）、抑制性T细胞（CD8）、辅助性T细胞（CD4）以及携带激活抗原（DR和Tac）的淋巴细胞数量进行了评估。结果显示，与年龄和性别匹配的对照组相比，急性大疱性类天疱疮急性期患者的全T细胞群（CD3）和抑制性T细胞亚群（CD8）数量正常，但辅助性T细胞亚群（CD4）以及DR和Tac阳性淋巴细胞数量显著增加。从表型上看，这些DR阳性细胞分别有66%属于全T细胞群（CD3），53%属于辅助性T细胞亚群（CD4）。在接受免疫抑制剂治疗后，细胞计数恢复正常，提示辅助性T细胞激活参与了急性大疱性类天疱疮的发病过程。
