Knudson C J, Varga S M
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA Department of Microbiology, University of Iowa, Iowa City, IA, USA Department of Pathology, University of Iowa, Iowa City, IA, USA
Vet Pathol. 2015 Jan;52(1):97-106. doi: 10.1177/0300985814520639. Epub 2014 Feb 10.
Asthma is a chronic inflammatory disease of the lung that is a leading cause of morbidity and mortality in children worldwide. Most infants who experience wheezing episodes also exhibit evidence of an ongoing respiratory viral infection. Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in children and is a common cause of wheezing in infants and young children. In the past several decades, a number of studies have demonstrated a relationship between infants with severe RSV infections and the subsequent development of asthma later during childhood. This review provides an overview of data that suggests a severe RSV infection early in childhood is linked to development of asthma later in life. In addition, the current and potential future use of various animal models to gain additional insight into the relationship between RSV and asthma is discussed.
哮喘是一种肺部慢性炎症性疾病，是全球儿童发病和死亡的主要原因。大多数经历喘息发作的婴儿也表现出正在进行的呼吸道病毒感染的迹象。呼吸道合胞病毒（RSV）是儿童下呼吸道感染的主要原因，也是婴幼儿喘息的常见原因。在过去几十年中，多项研究表明，患有严重RSV感染的婴儿与儿童期后期哮喘的后续发展之间存在关联。本综述概述了相关数据，这些数据表明儿童早期严重的RSV感染与生命后期哮喘的发展有关。此外，还讨论了目前以及未来可能使用各种动物模型来进一步深入了解RSV与哮喘之间的关系。
