Respiratory Care Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Complutense de Madrid, 28007 Madrid, Spain.
Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Viruses. 2024 Nov 7;16(11):1749. doi: 10.3390/v16111749.
(1) Background: To describe hospitalizations due to respiratory syncytial virus (RSV) infection among children and elderly patients with asthma. (2) Methods: We used a nationwide discharge database to select patients with asthma aged 0 to 15 years and ≥65 years admitted to Spanish hospitals from 2016 to 2022. (3) Results: We identified 49,086 children and 471,947 elderly patients hospitalized with asthma (3.52% and 0.51%, respectively, with RSV). The proportion of RSV increased over time in children with asthma (from 1.44% to 7.4%, < 0.001) and in elderly individuals (from 0.17% to 1.01%, < 0.001). Among children with RSV infection, the presence of influenza (OR 3.65; 95% CI 1.46-9.1) and pneumonia (OR 1.85; 95% CI 1.02-3.55) increased the risk of poor outcome. The presence of RSV was associated with severity in these patients, defined by use of mechanical ventilation and/or admission to the intensive care unit (OR 1.44; 95% CI 1.11-1.86). In elderly patients with RSV infection, older age, congestive heart failure, COVID-19, and pneumonia increased the risk of in-hospital mortality (IHM). However, RSV infection was not associated with IHM (OR 0.88; 95% CI 0.68-1.15) in these patients. (4) Conclusion: Our results highlight the impact of RSV infection in children and elderly patients hospitalized with asthma. Strategies to improve surveillance, prophylaxis, and management of RSV infection should be evaluated.
(1) 背景：描述儿童和老年哮喘患者因呼吸道合胞病毒（RSV）感染而住院的情况。
(2) 方法：我们使用全国性的出院数据库，选择 2016 年至 2022 年期间在西班牙医院住院的 0 至 15 岁和≥65 岁的哮喘患者。
(3) 结果：我们确定了 49086 名儿童和 471947 名老年哮喘患者（分别为 3.52%和 0.51%，伴有 RSV）。儿童哮喘患者中 RSV 的比例随时间推移而增加（从 1.44%增加到 7.4%，<0.001），老年患者中 RSV 的比例也增加（从 0.17%增加到 1.01%，<0.001）。在 RSV 感染的儿童中，流感（OR 3.65；95%CI 1.46-9.1）和肺炎（OR 1.85；95%CI 1.02-3.55）的存在增加了不良结局的风险。RSV 的存在与这些患者的严重程度相关，表现为使用机械通气和/或入住重症监护病房（OR 1.44；95%CI 1.11-1.86）。在感染 RSV 的老年患者中，年龄较大、充血性心力衰竭、COVID-19 和肺炎增加了院内死亡率（IHM）的风险。然而，RSV 感染与这些患者的 IHM 无关（OR 0.88；95%CI 0.68-1.15）。
(4) 结论：我们的结果强调了 RSV 感染对儿童和老年哮喘住院患者的影响。应评估改善 RSV 感染监测、预防和管理的策略。
