Aurello Paolo, Tierno Simone Maria, Berardi Giammauro, Tomassini Federico, Magistri Paolo, D'Angelo Francesco, Ramacciato Giovanni
Third Division of General Surgery, Sant'Andrea Hospital, University of Rome "La Sapienza", Rome, Italy,
Ann Surg Oncol. 2014 Jun;21(6):1998-2004. doi: 10.1245/s10434-014-3533-9. Epub 2014 Feb 11.
This study was designed to identify which are the best preoperative inflammation-based prognostic scores in terms of overall survival (OS) and disease-free survival (DFS) in patients with gastric cancer.
Between January 2004 and January 2013, 102 consecutive patients underwent resection for gastric cancer at S. Andrea Hospital, "La Sapienza", University of Rome. Their records were retrospectively reviewed.
After a median follow up of 40.8 months (8-107 months), patients' 1-, 3-, and 5-year OS rates were 88, 72, and 59 %, respectively. After R0 resection, the 1-, 3-, and 5-year DFS rates were 93, 74, and 56 %, respectively. A multivariate analysis of the significant variables showed that only the modified Glasgow prognostic scores (p < 0.001) and PI (p < 0.001) were independently associated with OS. Regarding DFS, multivariate analysis of the significant variables showed that the modified Glasgow prognostic score (p = 0.002) and prognostic index (p < 0.001) were independently associated with DFS.
The results of this study show that modified Glasgow prognostic score and prognostic index are independent predictors of OS and DFS in patients with gastric cancer.
本研究旨在确定在胃癌患者的总生存期（OS）和无病生存期（DFS）方面，哪些基于炎症的术前预后评分是最佳的。
2004年1月至2013年1月期间，罗马第一大学“La Sapienza”圣安德烈亚医院连续102例患者接受了胃癌切除术。对他们的病历进行了回顾性分析。
中位随访40.8个月（8 - 107个月）后，患者1年、3年和5年的总生存率分别为88%、72%和59%。R0切除术后，1年、3年和5年的无病生存率分别为93%、74%和56%。对显著变量进行多因素分析显示，只有改良格拉斯哥预后评分（p < 0.001）和预后指数（p < 0.001）与总生存期独立相关。关于无病生存期，对显著变量进行多因素分析显示，改良格拉斯哥预后评分（p = 0.002）和预后指数（p < 0.001）与无病生存期独立相关。
本研究结果表明，改良格拉斯哥预后评分和预后指数是胃癌患者总生存期和无病生存期的独立预测因素。
