外阴硬化性苔藓的前瞻性临床和流行病学研究：临床特征的流行率和严重程度分析，以及历史和人口统计学相关性。
Prospective clinical and epidemiologic study of vulvar lichen sclerosus: analysis of prevalence and severity of clinical features, together with historical and demographic associations.
机构信息
Department of Medical Sciences, Section of Dermatology, University of Ferrara, Ferrara, Italy.
出版信息
Dermatology. 2014;228(2):145-51. doi: 10.1159/000356163. Epub 2014 Feb 8.
BACKGROUND
Few reports have addressed the associations between clinical, demographic and historical variables of vulvar lichen sclerosus (VLS).
OBJECTIVE
To elaborate the prevalence and severity of signs and symptoms and to identify potential factors predicting the severity and course of VLS.
METHODS
A prospective cohort of 225 patients affected by VLS was included. Data were collected by direct interview and clinical examination.
RESULTS
98% of patients complained of symptoms, principally itching. Pallor and scarring-sclerosis-atrophy were the most frequent and severe signs. The severity of VLS signs was not associated with age at onset and duration of the disease. About 70% of the patients had previously undergone treatment.
CONCLUSIONS
VLS-related symptoms were not associated with the clinical features which resulted less severe. Personal history of autoimmune diseases and familial history of VLS did not influence the age at onset and the severity of VLS. A considerable part of patients had previously received inappropriate treatment.
背景
鲜有报告探讨外阴硬化性苔藓（VLS）的临床、人口统计学和病史变量之间的关联。
目的
阐述体征和症状的患病率和严重程度，并确定预测 VLS 严重程度和病程的潜在因素。
方法
纳入了 225 例患有 VLS 的患者进行前瞻性队列研究。通过直接访谈和临床检查收集数据。
结果
98%的患者有症状，主要是瘙痒。苍白、瘢痕-硬化-萎缩是最常见和最严重的体征。VLS 体征的严重程度与发病年龄和疾病持续时间无关。约 70%的患者曾接受过治疗。
结论
VLS 相关症状与临床表现的严重程度无关。自身免疫性疾病的个人史和 VLS 的家族史并不影响 VLS 的发病年龄和严重程度。相当一部分患者之前接受了不适当的治疗。
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