Adkins Chinessa T, Dobish Julia N, Brown Scott, Harth Eva
Department of Chemistry, Vanderbilt University, 7619 Stevenson Center, Nashville, Tennessee, USA.
ACS Macro Lett. 2013 Aug 20;2(8):710-714. doi: 10.1021/mz400370f.
Water-soluble semiconducting nanoparticles are prepared from individually collapsed and crosslinked ABA triblock copolymers and are further modified to carry imaging units and allyl functionalities for postmodification. Ethylene oxide modified polyfluorene forms the center block (B) and is transformed into a telechelic macroinitator. In a nitroxide mediated living free radical polymerization, polyacrylate blocks (A) are grown to give the ABA triblock copolymer. Low-temperature benzocyclobutene crosslinking groups are attached to collapse and site-isolate the center block (A). The nanoparticles were further modified by pegylation to enhance the solubility and by catechol groups to provide complexing sites for magnetic resonance imaging (MRI) reagents such as gadolinium. The reported materials are water-soluble and encompassing fluorescence and MRI to become biocompatible "organic quantum dots" with the possibility to interact actively with biological entities.
水溶性半导体纳米颗粒由单独折叠和交联的ABA三嵌段共聚物制备而成，并进一步进行修饰以携带成像单元和烯丙基官能团用于后修饰。环氧乙烷改性的聚芴形成中心嵌段（B），并转化为遥爪大分子引发剂。在氮氧化物介导的活性自由基聚合反应中，聚丙烯酸酯嵌段（A）生长形成ABA三嵌段共聚物。连接低温苯并环丁烯交联基团以使中心嵌段（A）折叠并进行位点隔离。纳米颗粒通过聚乙二醇化进一步修饰以提高溶解性，并通过儿茶酚基团提供用于钆等磁共振成像（MRI）试剂的络合位点。所报道的材料是水溶性的，兼具荧光和MRI功能，成为具有与生物实体主动相互作用可能性的生物相容性“有机量子点”。
