Ranjbar Mohammadmehdi, Varzi Hossein Najafzadeh, Sabbagh Atefeh, Bolooki Adeleh, Sazmand Alireza
Department of Pathobiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.
Pak J Biol Sci. 2013 Dec 15;16(24):2066-9. doi: 10.3923/pjbs.2013.2066.2069.
Cordia myxa is a plant which is used in tropical regions of the world. Analgesic and anti-inflammatory effect of fruit of this medicinal plant was investigated in mice. Hydro-alcoholic extract of it was prepared by maceration method. Formalin test was conducted in six groups of mice (6 animals in each group) and acetic acid test in another six groups (6 mice). Groups one to six in each test were administered normal saline, oral indomethacin, intraperitoneal tramadol, 100 mg kg(-1) oral extract, 200 mg kg(-1) oral extract and 100 mg kg(-1) intraperitoneal extract, respectively. The duration of foot lickings were calculated in formalin- administered (1st) group within min 0 to 5 (acute phase) and 15 to 25 (chronic phase). Acetic acid-induced writhings were counted within 10 min in the 2nd group. The results showed that hydro-alcoholic extract of Cordia myxa fruit was considerably effective in formalin test. Also, analgesic and anti-inflammatory properties of this plant's fruit in both acute and chronic phase are somewhat similar to these properties in the study on animal model of experimental colitis.
紫铆树是一种生长在世界热带地区的植物。对这种药用植物果实的镇痛和抗炎作用在小鼠身上进行了研究。其水醇提取物采用浸渍法制备。在六组小鼠（每组6只动物）中进行福尔马林试验，在另外六组（6只小鼠）中进行醋酸试验。在每次试验中，第一至六组分别给予生理盐水、口服吲哚美辛、腹腔注射曲马多、100 mg kg(-1)口服提取物、200 mg kg(-1)口服提取物和100 mg kg(-1)腹腔注射提取物。在给予福尔马林的（第一）组中，计算0至5分钟（急性期）和15至25分钟（慢性期）内舔足的持续时间。在第二组中，在10分钟内计数醋酸诱导的扭体次数。结果表明，紫铆树果实的水醇提取物在福尔马林试验中具有显著效果。此外，这种植物果实在急性期和慢性期的镇痛和抗炎特性与实验性结肠炎动物模型研究中的这些特性有些相似。
