紫星二酮的全合成。
Total synthesis of asterredione.
作者信息
Gai Sinan, Zhang Qing, Hu Xiangdong
机构信息
Department of Chemistry & Material Science, Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education of China, Northwest University , Xi'an 710069, China.
出版信息
J Org Chem. 2014 Mar 7;79(5):2111-4. doi: 10.1021/jo4028177. Epub 2014 Feb 17.
The first total synthesis of asterredione was efficiently accomplished over five linear steps and in 21.5% overall yield. As the crucial step, the 2-quaternary 1,3-cyclopentenedione skeleton of asterredione was readily achieved using the Darzens/ring-expansion strategy developed in our laboratory. The structure of synthesized asterredione was fully confirmed by X-ray crystallography.
通过五个线性步骤高效完成了asterredione的首次全合成，总产率为21.5%。作为关键步骤，使用我们实验室开发的Darzens/扩环策略轻松实现了asterredione的2-季碳1,3-环戊二酮骨架。合成的asterredione的结构通过X射线晶体学得到了充分证实。
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