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本文引用的文献

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Properties and prospects of adjuvants in influenza vaccination - messy precipitates or blessed opportunities?流感疫苗接种中佐剂的特性与前景——是棘手的沉淀物还是天赐良机？
Mol Cell Ther. 2013 Nov 6;1:2. doi: 10.1186/2052-8426-1-2. eCollection 2013.
2
Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen.年龄是乙型肝炎表面抗原免疫后体液和 T 细胞反应的一个重要决定因素。
Hum Vaccin Immunother. 2013 Jul;9(7):1466-76. doi: 10.4161/hv.24480. Epub 2013 Apr 9.
3
Age-related decrease of miRNA-92a levels in human CD8+ T-cells correlates with a reduction of naïve T lymphocytes.人类 CD8+ T 细胞中 miRNA-92a 水平随年龄相关的下降与幼稚 T 淋巴细胞的减少相关。
Immun Ageing. 2011 Nov 15;8(1):11. doi: 10.1186/1742-4933-8-11.
4
CD28(-) T cells: their role in the age-associated decline of immune function.CD28阴性T细胞：它们在与年龄相关的免疫功能衰退中的作用。
Trends Immunol. 2009 Jul;30(7):306-12. doi: 10.1016/j.it.2009.03.013. Epub 2009 Jun 18.
5
CD50 and CD62L adhesion receptor expression on naive (CD45RA+) and memory (CD45RO+) T lymphocytes in the elderly.老年人中初始（CD45RA+）和记忆（CD45RO+）T淋巴细胞上CD50和CD62L黏附受体的表达
Pathobiology. 2000;68(6):245-50. doi: 10.1159/000055933.

对Shin和Bayry所著《CD62L与疫苗反应的年龄相关性下降：微小RNA 92a的作用？》的回复

Reply to Shin and Bayry on "An age-related decline of CD62L and vaccine response: a role of microRNA 92a?".

作者信息

Vorup-Jensen Thomas, Rosenberg Carina, Petersen Eskild

机构信息

Department of Biomedicine; Aarhus University; Aarhus, Denmark.

Department of Clinical Medicine; Aarhus University; Aarhus, Denmark; Department of Infectious Diseases; Aarhus University Hospital-Skejby; Aarhus, Denmark.

出版信息

Hum Vaccin Immunother. 2014;10(5):1406-7. doi: 10.4161/hv.27843. Epub 2014 Feb 11.

DOI:10.4161/hv.27843
PMID:24518554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4896509/
Abstract

Aging of the human body affects the immune system by a decline in the ability to raise a response to challenges such as microbial infections or vaccinations. In the very elderly, the decline in such functions appears to relate to a reduced expression of certain co-stimulatory molecules expressed by T lymphocytes. More recently, attention has been drawn to the adhesion molecule CD62L, where differences in expression and function of this molecule between younger and older individuals are suspected to be a part of immunosenescence in the elderly.

摘要

人体衰老会影响免疫系统，其应对微生物感染或疫苗接种等挑战的反应能力会下降。在高龄老人中，此类功能的下降似乎与T淋巴细胞表达的某些共刺激分子的表达减少有关。最近，黏附分子CD62L受到关注，年轻个体与老年个体之间该分子在表达和功能上的差异被怀疑是老年人免疫衰老的一部分。