de Oliveira Renata Ferreira, de Andrade Salgado Daniela Miranda Richarte, Trevelin Lívia Tosi, Lopes Raquel Marianna, da Cunha Sandra Ribeiro Barros, Aranha Ana Cecília Correa, de Paula Eduardo Carlos, de Freitas Patricia Moreira
Department of Restorative Dentistry, Special Laboratory of Lasers in Dentistry (LELO), School of Dentistry, University of São Paulo, São Paulo, Brazil.
Lasers Med Sci. 2015 May;30(4):1395-406. doi: 10.1007/s10103-014-1531-6. Epub 2014 Feb 12.
Post-traumatic nerve repair represents a major challenge to health sciences. Although there have been great advances in the last few years, it is still necessary to find methods that can effectively enhance nerve regeneration. Laser therapy has been widely investigated as a potential method for nerve repair. Therefore, in this article, a review of the existing literature was undertaken with regard to the effects of low-power laser irradiation on the regeneration of traumatically/surgically injured nerves. The articles were selected using either electronic search engines or manual tracing of the references cited in key papers. In electronic searches, we used the key words as "paresthesia", "laser therapy", "low-power laser and nerve repair", and "laser therapy and nerve repair", considering case reports and clinical studies. According to the findings of the literature, laser therapy accelerates and improves the regeneration of the affected nerve tissues, but there are many conflicting results about laser therapy. This can be attributed to several variables such as wavelength, radiation dose, and type of radiation. All the early in vivo studies assessed in this research were effective in restoring sensitivity. Although these results indicate a potential benefit of the use of lasers on nerve repair, further double-blind controlled clinical trials should be conducted in order to standardize protocols for clinical application.
创伤后神经修复是健康科学面临的一项重大挑战。尽管在过去几年里取得了巨大进展,但仍有必要找到能够有效促进神经再生的方法。激光疗法作为一种潜在的神经修复方法已得到广泛研究。因此,在本文中,我们对现有文献进行了综述,探讨低功率激光照射对创伤性/手术损伤神经再生的影响。文章通过电子搜索引擎或手动追踪关键论文中引用的参考文献来选取。在电子搜索中,考虑到病例报告和临床研究,我们使用了“感觉异常”、“激光疗法”、“低功率激光与神经修复”以及“激光疗法与神经修复”等关键词。根据文献研究结果,激光疗法可加速并改善受损神经组织的再生,但关于激光疗法存在许多相互矛盾的结果。这可能归因于几个变量,如波长、辐射剂量和辐射类型。本研究评估的所有早期体内研究在恢复感觉方面均有效。尽管这些结果表明激光在神经修复方面具有潜在益处,但为了规范临床应用方案,仍应进行进一步的双盲对照临床试验。