Department of Chemistry, Northwestern University, 2145 Sheridan Rd, Evanston, IL 60208 (USA).
Angew Chem Int Ed Engl. 2014 Mar 10;53(11):2988-91. doi: 10.1002/anie.201310060. Epub 2014 Feb 12.
The total synthesis of sculponeatin N, a bioactive polycyclic diterpene isolated from Isodon sculponeatus, is reported. Key features of the synthesis include diastereoselective Nazarov and ring-closing metathesis reactions, and a highly efficient formation of the bicyclo[3.2.1]octane ring system by a reductive radical cyclization.
报道了从兰香草中分离得到的具有生物活性的多环二萜化合物 sculponeatin N 的全合成。该合成的关键步骤包括非对映选择性 Nazarov 反应和环 closing metathesis 反应，以及通过还原自由基环化反应高效构建双环[3.2.1]辛烷环系。
