三叶香茶菜中的新二萜化合物 ternifolide A，具有罕见大环内酯骨架。

Ternifolide A, a new diterpenoid possessing a rare macrolide motif from Isodon ternifolius.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.

出版信息

Org Lett. 2012 Jun 15;14(12):3210-3. doi: 10.1021/ol3013205. Epub 2012 May 31.

DOI:10.1021/ol3013205

PMID:22651671

Abstract

Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being α-orientations in compound 1 were found for the first time. The absolute configurations of 1 and 3 were confirmed by X-ray diffraction study. Compounds 1 and 3 were evaluated for their cytotoxicity.

摘要

从三叶香茶菜的叶子中分离得到了一种新的二萜化合物 1，其特征是在 C-6 和 C-15 之间形成了一个独特的 10 元内酯环，此外还有二萜化合物 2 和 3。在化合物 1 中首次发现 H-8 和 H-9 均为α-取向。通过 X 射线衍射研究确定了 1 和 3 的绝对构型。对化合物 1 和 3 的细胞毒性进行了评价。