通过光声显微镜对小鼠子宫内膜异位症进行的体内研究。

In vivo study of endometriosis in mice by photoacoustic microscopy.

作者信息

Ding Yichen, Zhang Mingzhu, Lang Jinghe, Leng Jinhua, Ren Qiushi, Yang Jie, Li Changhui

机构信息

Department of Biomedical Engineering, College of Engineering, Peking University, No. 5 Yiheyuan Road, Beijing, 100871, China.

出版信息

J Biophotonics. 2015 Jan;8(1-2):94-101. doi: 10.1002/jbio.201300189. Epub 2014 Feb 11.

DOI:10.1002/jbio.201300189

PMID:24519971

Abstract

Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photoacoustic microscopy (PAM) was employed to study the EM on the mouse model. Our results demonstrated the PAM noninvasively provided the high contrast and 3D imaging of subcutaneously implanted EM tissue in the nude mouse in vivo. The statistical study also indicated PAM had high sensitivity and specificity in the diagnosis of EM in this animal study. In addition, we also discussed the potential clinical application for PAM in the diagnosis of EM.

摘要

子宫内膜异位症（EM）会影响育龄女性的健康和生活质量。然而，无论是动物研究还是临床应用，都没有可靠的非侵入性诊断方法。在这项工作中，一种新型成像方法——光声显微镜（PAM）被用于研究小鼠模型中的子宫内膜异位症。我们的结果表明，PAM能够在体内对裸鼠皮下植入的EM组织进行非侵入性的高对比度三维成像。统计研究还表明，在这项动物研究中，PAM对EM的诊断具有高灵敏度和特异性。此外，我们还讨论了PAM在EM诊断中的潜在临床应用。