经口激光显微手术治疗下咽后壁鳞状细胞癌的肿瘤学结果。
Oncologic results of transoral laser microsurgery for squamous cell carcinoma of the posterior pharyngeal wall.
作者信息
Canis Martin, Wolff Hendrik A, Ihler Friedrich, Matthias Christoph, Steiner Wolfgang
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen, Germany.
出版信息
Head Neck. 2015 Feb;37(2):156-61. doi: 10.1002/hed.23571. Epub 2014 Feb 12.
BACKGROUND
The purpose of this study was to evaluate oncologic outcomes of transoral laser microsurgery (TLM) in patients with cancer of the oropharyngeal and/or hypopharyngeal posterior wall.
METHODS
Between August 1986 and December 2006, 25 patients (oropharyngeal n = 12; hypopharyngeal n = 13) were treated by primary CO2 laser microsurgery. Treatment was exclusively TLM with or without selective neck dissection in 12 cases (48%); TLM with adjuvant (chemo)radiotherapy was performed in 13 cases (52%).
RESULTS
Data were analyzed by using the Kaplan-Meier method. The median follow-up was 41.6 months. The 5-year overall, recurrence-free, and disease-specific survival rates for stages I/II were 36,5%, 60,0%, and 87,5% and for stages III/IVa 41,2%, 36,4%, and 56,3%, respectively.
CONCLUSION
With respect to local control and survival, results are comparable to conventional surgery.
背景
本研究旨在评估经口激光显微手术（TLM）治疗口咽和/或下咽后壁癌患者的肿瘤学结局。
方法
1986年8月至2006年12月期间，25例患者（口咽癌12例；下咽癌13例）接受了原发性二氧化碳激光显微手术治疗。12例患者（48%）仅接受了TLM手术，其中部分患者接受了选择性颈清扫术；13例患者（52%）接受了TLM联合辅助（化疗）放疗。
结果
采用Kaplan-Meier方法对数据进行分析。中位随访时间为41.6个月。I/II期患者的5年总生存率、无复发生存率和疾病特异性生存率分别为36.5%、60.0%和87.5%，III/IVa期患者分别为41.2%、36.4%和56.3%。
结论
在局部控制和生存率方面，结果与传统手术相当。
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