Department of Dermatology, School of Medicine, Cardiff University, Wales, UK; Northern Rivers Skin Cancer Clinic, Ballina, NSW, Australia.
Dermatol Pract Concept. 2014 Jan 31;4(1):77-82. doi: 10.5826/dpc.0401a13. eCollection 2014 Jan.
The dermatoscopic features of facial lentigo maligna (LM), facial lentigo maligna melanoma (LMM) and acral lentiginous melanoma (ALM) have been well described. This is the first description of the dermatoscopic appearance of a clinical series of cutaneous non-facial non-acral lentiginous growth pattern melanomas.
To describe the dermatoscopic features of a series of cutaneous non-facial non-acral lentiginous growth pattern melanomas in an Australian skin cancer practice.
Single observer retrospective analysis of dermatoscopic images of a one-year series of cutaneous non-facial, non-acral melanomas reported as having a lentiginous growth pattern detected in an open access primary care skin cancer clinic in Australia. Lesions were scored for presence of classical criteria for facial LM; modified pattern analysis ("Chaos and Clues") criteria; and the presence of two novel criteria: a lentigo-like pigment pattern lacking a lentigo-like border, and large polygons.
20 melanomas occurring in 14 female and 6 male patients were included. Average patient age was 64 years (range: 44-83). Lesion distribution was: trunk 35%; upper limb 40%; and lower limb 25%. The incidences of criteria identified were: asymmetry of color or pattern (100%); lentigo-like pigment pattern lacking a lentigo-like border (90%); asymmetrically pigmented follicular openings (APFO's) (70%); grey blue structures (70%); large polygons (45%); eccentric structureless area (15%); bright white lines (5%). 20% of the lesions had only the novel criteria and/or APFO's.
Single observer, single center retrospective study.
Cutaneous non-facial non-acral melanomas with a lentiginous growth pattern may have none or very few traditional criteria for the diagnosis of melanoma. Criteria that are logically expected in lesions with a lentiginous growth pattern (lentigo-like pigment pattern lacking a lentigo-like border, APFO's) and the novel criterion of large polygons may be useful in increasing sensitivity and specificity of diagnosis of these lesions. Further study is required to establish the significance of these observations.
面部恶性雀斑样痣（LM）、面部恶性雀斑样黑素瘤（LMM）和肢端雀斑样黑素瘤（ALM）的皮肤镜特征已有详细描述。这是首次描述一系列临床皮肤非面部非肢端雀斑样生长模式黑素瘤的皮肤镜表现。
描述澳大利亚皮肤癌诊所一系列皮肤非面部非肢端雀斑样生长模式黑素瘤的皮肤镜特征。
对澳大利亚一家开放获取的初级保健皮肤癌诊所检测到的具有雀斑样生长模式的一年期皮肤非面部、非肢端黑素瘤系列进行单观察者回顾性分析。对存在经典面部 LM 标准、改良模式分析（“混乱与线索”）标准和两个新的标准的病变进行评分：缺乏类似雀斑边界的类似雀斑样色素模式和大多边形。
纳入 14 名女性和 6 名男性共 20 例黑素瘤患者。患者平均年龄为 64 岁（范围：44-83 岁）。病变分布为：躯干 35%；上肢 40%；下肢 25%。鉴定出的标准的发生率为：颜色或模式的不对称性（100%）；缺乏类似雀斑边界的类似雀斑样色素模式（90%）；不对称色素性毛囊开口（APFO）（70%）；灰色蓝色结构（70%）；大多边形（45%）；偏心无结构区（15%）；亮白线（5%）。20%的病变仅有新的标准和/或 APFO。
单观察者、单中心回顾性研究。
具有雀斑样生长模式的皮肤非面部非肢端黑素瘤可能没有或仅有很少的黑色素瘤诊断传统标准。逻辑上预期在具有雀斑样生长模式的病变中存在的标准（缺乏类似雀斑边界的类似雀斑样色素模式、APFO）和大多边形的新标准可能有助于提高这些病变的诊断敏感性和特异性。需要进一步研究来确定这些观察结果的意义。
