Li Yu-Hong, Waldréus Nana, Zdolsek Joachim, Hahn Robert G
Yu-Hong Li, Department of Anesthesia, College of Medicine, Zhejiang University, 310058 Hangzhou, Zhejiang Province, China.
World J Exp Med. 2012 Feb 20;2(1):1-6. doi: 10.5493/wjem.v2.i1.1.
To contrast the effects of various modifications of body fluid volumes on thirst as reported by healthy volunteers.
Ten male volunteers aged between 19 and 37 years (mean 22 years) underwent four experiments each, which comprised infusion of 400-800 mL of acetated Ringer's solution and intake of 600 mL of tap water. Half of the experiments were preceded by volume depletion (median 1.7 L) with furosemide. A visual analogue scale (0-100 mm) was used to assess perceived thirst during each experiment.
Volume depletion (P < 0.001) and tap water (P < 0.03) both affected thirst by 13 mm per L of fluid, whereas spontaneous diuresis and infusion of Ringer's acetate did not significantly change the thirst rating (multiple regressions). More detailed analyses showed that the volume depletion increased the median (25th-75th percentiles) thirst rating from 28 mm (21-43) to 59 mm (46-72, P < 0.001) while no change occurred in those who were only slightly thirsty (< 30 mm) before the volume depletion began. Ringer's solution alleviated thirst in those who were very thirsty, but tended to increase thirst in the volunteers who were not thirsty before the infusion. Similarly, hydration with tap water decreased thirst (by 24 mm, P < 0.04) in those who were thirsty (> 60 mm) while the others reported no change.
The change in thirst rating during volume depletion, administration of Ringer's acetate, and ingestion of tap water were all dependent on the thirst rating obtained when the manipulation of the body fluid volume was initiated.
对比健康志愿者报告的不同体液量改变对口渴的影响。
10名年龄在19至37岁（平均22岁）的男性志愿者每人进行4次实验，包括输注400 - 800毫升醋酸林格液以及摄入600毫升自来水。半数实验在使用速尿导致容量耗竭（中位数1.7升）后进行。每次实验期间使用视觉模拟量表（0 - 100毫米）评估主观口渴程度。
容量耗竭（P < 0.001）和自来水（P < 0.03）对口渴的影响均为每升液体使口渴程度改变13毫米，而自发性利尿和输注醋酸林格液未显著改变口渴评分（多元回归分析）。更详细的分析表明，容量耗竭使口渴评分中位数（第25 - 75百分位数）从28毫米（21 - 43）增至59毫米（46 - 72，P < 0.001），而在容量耗竭开始前仅有轻微口渴（< 30毫米）的人则无变化。林格液缓解了非常口渴者的口渴，但往往会增加输注前不口渴志愿者的口渴程度。同样，自来水补水使口渴者（> 60毫米）的口渴程度降低（降低24毫米，P < 0.04），而其他志愿者则无变化。
容量耗竭、输注醋酸林格液和摄入自来水期间口渴评分的变化均取决于开始改变体液量时的口渴评分。
