Kakisaka Yosuke, Uematsu Mitsugu, Wang Zhong I, Haginoya Kazuhiro
Yosuke Kakisaka, Mitsugu Uematsu, Kazuhiro Haginoya, Department of Pediatrics, Tohoku University School of Medicine, Sendai, Miyagi 980-8574, Japan.
World J Exp Med. 2012 Aug 20;2(4):75-7. doi: 10.5493/wjem.v2.i4.75.
Despite the 2%-5% prevalence of abdominal migraine (AM) during childhood, the precise mechanism remains unknown. In this review, we present recent studies on AM and speculate its mechanism from both peripheral and central nervous system aspects. Although the main symptoms of AM exist at the peripheral level, previous studies have reported possible dysfunction of central nervous system, including photophobia, phonophobia and abnormal visual evoked responses. Recently, a case has been reported with AM combined with "Alice in Wonderland" syndrome with visual and/or bodily distortions, which serves as another piece of evidence of central dysfunction. Another case reported an AM patient having peculiar stereotypical ecchymosis in the legs and buttocks associated with pain attack, which implied possible involvement of peripheral nervous system. Although further investigations and accumulation of AM cases are still needed, we believe that the schema hypothesized here is helpful to plan further experimental approach to clarify the mechanism of this peculiar disease.
尽管儿童腹型偏头痛（AM）的患病率为2%-5%，但其确切机制仍不清楚。在本综述中，我们介绍了关于AM的最新研究，并从外周和中枢神经系统方面推测其机制。虽然AM的主要症状出现在外周水平，但先前的研究报告了中枢神经系统可能存在功能障碍，包括畏光、畏声和异常视觉诱发电位。最近，有一例AM合并“爱丽丝梦游仙境”综合征的病例报告，伴有视觉和/或身体变形，这是中枢功能障碍的又一证据。另一例报告称，一名AM患者在腿部和臀部出现与疼痛发作相关的特殊刻板瘀斑，这意味着外周神经系统可能受累。尽管仍需要进一步的研究和积累AM病例，但我们相信这里假设的模式有助于规划进一步的实验方法，以阐明这种特殊疾病的机制。
