载脂蛋白B的DNA与蛋白质多态性之间的关系。
Relationships between DNA and protein polymorphisms of apolipoprotein B.
作者信息
Dunning A M, Tikkanen M J, Ehnholm C, Bütler R, Humphries S E
机构信息
Charing Cross Sunley Research Centre, Hammersmith, London, UK.
出版信息
Hum Genet. 1988 Apr;78(4):325-9. doi: 10.1007/BF00291728.
The associations between four restriction fragment length polymorphisms (RFLPs) of the gene for human apolipoprotein B (apo B) and five antigen group (Ag) protein-polymorphisms of apo B have been investigated in 24 unrelated Finnish individuals. In this sample a complete correlation exists between the EcoRI RFLP and the Ag(t/z) polymorphism. There is strong association between the alleles of the XbaI RFLP and Ag(c/g) and a weaker one of the same XbaI site with Ag(x/y). Linkage disequilibrium is observed between the PvuII RFLP and the Ag(a1/d) polymorphism. These associations confirm that the Ag variants are true protein sequence polymorphisms of apo B.
在24名无亲缘关系的芬兰个体中，研究了人类载脂蛋白B（apo B）基因的四种限制性片段长度多态性（RFLP）与apo B的五种抗原组（Ag）蛋白多态性之间的关联。在这个样本中，EcoRI RFLP与Ag(t/z)多态性之间存在完全相关性。XbaI RFLP的等位基因与Ag(c/g)之间存在强关联，而同一XbaI位点与Ag(x/y)之间的关联较弱。在PvuII RFLP与Ag(a1/d)多态性之间观察到连锁不平衡。这些关联证实了Ag变体是apo B真正的蛋白质序列多态性。
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