Immunogenetic polymorphism of apolipoprotein B in humans: studies with a monoclonal anti-Ag(c) antibody.

In studies that use a monoclonal antibody (MB-19), apolipoprotein B exhibited one of three immunophenotypes: high, intermediate, or low affinity binding to this antibody. The distribution of these immunophenotypes (allotypes) in families was compatible with a codominant transmission of two alleles, one coding for the high and the other for the low affinity binding allotype. The high affinity binding allotype coincided with antigen Ag(c) and the low affinity binding allotype with Ag(g), two allelic antigenic determinants previously defined by human antisera. Preliminary studies did not reveal differences in plasma lipid levels in association with apolipoprotein B allotypes. Young Finnish men with low affinity binding apolipoprotein B had slightly lower plasma apolipoprotein B levels than those with the intermediate affinity binding phenotype.