Tikkanen M J
Am Heart J. 1987 Feb;113(2 Pt 2):428-32. doi: 10.1016/0002-8703(87)90609-0.
In studies that use a monoclonal antibody (MB-19), apolipoprotein B exhibited one of three immunophenotypes: high, intermediate, or low affinity binding to this antibody. The distribution of these immunophenotypes (allotypes) in families was compatible with a codominant transmission of two alleles, one coding for the high and the other for the low affinity binding allotype. The high affinity binding allotype coincided with antigen Ag(c) and the low affinity binding allotype with Ag(g), two allelic antigenic determinants previously defined by human antisera. Preliminary studies did not reveal differences in plasma lipid levels in association with apolipoprotein B allotypes. Young Finnish men with low affinity binding apolipoprotein B had slightly lower plasma apolipoprotein B levels than those with the intermediate affinity binding phenotype.
在使用单克隆抗体（MB - 19）的研究中，载脂蛋白B呈现出三种免疫表型之一：与该抗体的高亲和力结合、中等亲和力结合或低亲和力结合。这些免疫表型（同种异型）在家族中的分布与两个等位基因的共显性传递相符，一个等位基因编码高亲和力结合同种异型，另一个编码低亲和力结合同种异型。高亲和力结合同种异型与抗原Ag(c)一致，低亲和力结合同种异型与Ag(g)一致，Ag(c)和Ag(g)是先前由人抗血清定义的两个等位基因抗原决定簇。初步研究未发现与载脂蛋白B同种异型相关的血浆脂质水平差异。具有低亲和力结合载脂蛋白B的年轻芬兰男性的血浆载脂蛋白B水平略低于具有中等亲和力结合表型的男性。
