靶向自身免疫性疾病中的 Fc 受体。
Targeting the Fc receptor in autoimmune disease.
机构信息
The University of Alabama , SHEL 272, 1825 University Blvd, Birmingham, AL 35294 , USA.
出版信息
Expert Opin Ther Targets. 2014 Mar;18(3):335-50. doi: 10.1517/14728222.2014.877891.
INTRODUCTION
The Fc receptors (FcRs) and their interactions with immunoglobulin and innate immune opsonins, such as C-reactive protein, are key players in humoral and cellular immune responses. As the effector mechanism for some therapeutic monoclonal antibodies, and often a contributor to the pathogenesis and progression of autoimmunity, FcRs are promising targets for treating autoimmune diseases.
AREAS COVERED
This review discusses the nature of different FcRs and the various mechanisms of their involvement in initiating and modulating immunocyte functions and their biological consequences. It describes a range of current strategies in targeting FcRs and manipulating their interaction with specific ligands, while presenting the pros and cons of these approaches. This review also discusses potential new strategies including regulation of FcR expression and receptor crosstalk.
EXPERT OPINION
FcRs are appealing targets in the treatment of inflammatory autoimmune diseases. However, there are still knowledge limitations and technical challenges, the most important being a better understanding of the individual roles of each of the FcRs and enhancement of the specificity in targeting particular cell types and specific FcRs.
简介
Fc 受体（FcRs）及其与免疫球蛋白和先天免疫调理蛋白（如 C 反应蛋白）的相互作用是体液和细胞免疫反应的关键因素。作为一些治疗性单克隆抗体的效应机制，并且常常是自身免疫发病机制和进展的促成因素，FcRs 是治疗自身免疫性疾病的有前途的靶点。
涵盖领域
本文综述了不同 FcR 的性质以及它们参与启动和调节免疫细胞功能及其生物学后果的各种机制。描述了一系列针对 FcR 的当前策略以及操纵它们与特定配体相互作用的方法，同时提出了这些方法的优缺点。本文还讨论了一些新的潜在策略，包括调节 FcR 的表达和受体串扰。
专家意见
FcR 是治疗炎症性自身免疫性疾病的有吸引力的靶点。然而，仍然存在知识局限性和技术挑战，最重要的是更好地了解每个 FcR 的个体作用，并提高针对特定细胞类型和特定 FcR 的靶向特异性。
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