School of Chemistry and Chemical Engineering, Yangzhou University , 180 Siwangting Street, Yangzhou 225002, P. R. China.
ACS Comb Sci. 2014 Mar 10;16(3):113-9. doi: 10.1021/co4001502. Epub 2014 Feb 17.
An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes and Meldrum's acid for the generation of a wide range of structurally interesting and pharmacologically significant compounds.
现已开发出一种高效且直接的合成方案，可通过芳醛、乙酸铵、取代的β-硝基苯乙烯和梅德姆酸之间的拟五组分反应，实现含梅德姆酸部分的高度官能化哌啶的多样性导向合成，从而生成广泛的具有结构趣味性和药理学意义的化合物。
