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五组分反应的最新进展

Recent Developments on Five-Component Reactions.

机构信息

School of Pharmacy, Changzhou University, 1 Gehu Road, Changzhou 213164, China.

Jiangsu Key Laboratory for the Chemistry of Low-Dimensional Materials, Huaiyin Normal University, Huai'an 223300, China.

出版信息

Molecules. 2021 Apr 1;26(7):1986. doi: 10.3390/molecules26071986.

DOI:10.3390/molecules26071986
PMID:33915870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8037922/
Abstract

Multicomponent reactions (MCRs) have inherent advantages in pot, atom, and step economy (PASE). This important green synthetic approach has gained increasing attention due to high efficiency, minimal waste, saving resources, and straightforward procedures. Presented in this review article are the recent development on 5-compoment reactions (5CRs) of the following six types: (I) five different molecules A + B + C + D + E; pseudo-5CRs including (II) 2A + B + C + D, (III) 2A + 2B + C, (IV) 3A + B + C, (V) 3A + 2B, and (VI) 4A + B. 5CRs with more than five-reaction centers are also included.

摘要

多组分反应（MCRs）在釜、原子和步骤经济性（PASE）方面具有内在优势。由于高效、最小化废物、节约资源和简单的程序，这种重要的绿色合成方法受到了越来越多的关注。本文综述了以下六种 5 组分反应（5CRs）的最新发展：（I）五个不同分子 A + B + C + D + E；拟 5CRs 包括（II）2A + B + C + D、（III）2A + 2B + C、（IV）3A + B + C、（V）3A + 2B 和（VI）4A + B。还包括具有五个以上反应中心的 5CRs。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/ea170cd51880/molecules-26-01986-sch023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/6339393dfeaf/molecules-26-01986-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/99c619b02b78/molecules-26-01986-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/af26fe502bc6/molecules-26-01986-sch002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/7f41b5f4b3a9/molecules-26-01986-sch008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/026e18cbf774/molecules-26-01986-sch011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/1906895ac752/molecules-26-01986-sch012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/9cee55f2a241/molecules-26-01986-sch013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/e8ddfaeb8abe/molecules-26-01986-sch014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/a5319680e241/molecules-26-01986-sch015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/c8928cb88a90/molecules-26-01986-sch017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/e4d92a0a45eb/molecules-26-01986-sch019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/a693344de32e/molecules-26-01986-sch021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/ea170cd51880/molecules-26-01986-sch023.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/6339393dfeaf/molecules-26-01986-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/460929792c32/molecules-26-01986-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/99c619b02b78/molecules-26-01986-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/af26fe502bc6/molecules-26-01986-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/546a9c9271df/molecules-26-01986-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/b10e3673e0e9/molecules-26-01986-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/bb3c8ff7d27c/molecules-26-01986-sch005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/41edfba13fab/molecules-26-01986-sch006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/e48bf81e8680/molecules-26-01986-sch007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/7f41b5f4b3a9/molecules-26-01986-sch008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/2cb13e19d052/molecules-26-01986-sch009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/3746519ce0a0/molecules-26-01986-sch010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/026e18cbf774/molecules-26-01986-sch011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/1906895ac752/molecules-26-01986-sch012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/9cee55f2a241/molecules-26-01986-sch013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/e8ddfaeb8abe/molecules-26-01986-sch014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/a5319680e241/molecules-26-01986-sch015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/c8928cb88a90/molecules-26-01986-sch017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/e4d92a0a45eb/molecules-26-01986-sch019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/a693344de32e/molecules-26-01986-sch021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a330/8037922/ea170cd51880/molecules-26-01986-sch023.jpg

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