Tazaki Masakazu, Endoh Takayuki, Kobayashi Hiroshi, Ohkubo Mai, Sueishi Kenji
Department of Physiology, Tokyo Dental College.
Bull Tokyo Dent Coll. 2013;54(4):275-8. doi: 10.2209/tdcpublication.54.275.
Angiotensin II (Ang II) plays a major role in the maintenance of extracellular fluid volume and blood pressure. In addition to its well-established role in circulatory homeostasis, it has been implicated in the process of bone formation. Osteoblasts play a major role in bone formation, employing intracellular Ca(2+) as a second messenger to modulate hormonal responses and as a cofactor for mineralization. Voltage-dependent Ca(2+) channels (VDCCs) mediate the influx of Ca(2+) in response to membrane depolarization. The purpose of this study was to investigate the effects of Ang II on VDCC currents in osteoblasts using a patch-clamp recording method. To our knowledge, the data presented here demonstrate for the first time that Ang II facilitates VDCCs in osteoblasts.
血管紧张素II（Ang II）在维持细胞外液容量和血压方面发挥着重要作用。除了在循环稳态中已确立的作用外，它还与骨形成过程有关。成骨细胞在骨形成中起主要作用，利用细胞内Ca(2+)作为第二信使来调节激素反应，并作为矿化的辅助因子。电压依赖性Ca(2+)通道（VDCCs）介导Ca(2+)响应膜去极化而内流。本研究的目的是使用膜片钳记录方法研究Ang II对成骨细胞中VDCC电流的影响。据我们所知，此处呈现的数据首次证明Ang II可促进成骨细胞中的VDCCs。
