De Rosa Salvatore, Curcio Antonio, Indolfi Ciro
Division of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University.
Circ J. 2014;78(3):567-75. doi: 10.1253/circj.cj-14-0086. Epub 2014 Feb 13.
Despite the recent progress in the diagnosis and treatment of cardiovascular diseases, these are still a major source of morbidity and mortality worldwide. For this reason, a large research effort was directed to the identification of the underlying pathophysiological aspects of cardiovascular diseases. Nevertheless, many mechanisms still need to be more deeply investigated, limiting the development of efficient diagnostic and therapeutic strategies for a relevant number of patients. Recently, microRNAs (miRs) emerged as powerful regulators of biological processes, offering a further opportunity to better understand the biological mechanisms responsible for the development of cardiovascular diseases, including cellular function and cell-to-cell communication. At the same time, the recent demonstration that cell-derived circulating miRs can be measured in the blood opens up their use as powerful biomarkers. The present review summarizes the most relevant experimental evidences on the involvement of miRs in cardiovascular diseases, including vascular remodeling, coronary artery disease, heart failure and ischemic stroke, thus highlighting potential targets for novel therapeutic strategies.
尽管近年来心血管疾病的诊断和治疗取得了进展，但在全球范围内，这些疾病仍是发病和死亡的主要原因。因此，大量研究致力于确定心血管疾病潜在的病理生理方面。然而，许多机制仍需更深入地研究，这限制了针对相当一部分患者的有效诊断和治疗策略的发展。最近，微小RNA（miRs）作为生物过程的强大调节因子出现，为更好地理解导致心血管疾病发展的生物学机制（包括细胞功能和细胞间通讯）提供了进一步的机会。同时，最近有证据表明可以在血液中检测到细胞衍生的循环miRs，这使得它们有望成为强大的生物标志物。本综述总结了关于miRs参与心血管疾病（包括血管重塑、冠状动脉疾病、心力衰竭和缺血性中风）的最相关实验证据，从而突出了新型治疗策略的潜在靶点。
