Department of Neuroregeneration, Institute of Experimental Medicine of the Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Department of Neuroscience, 2nd Medical Faculty, Charles University, 150 00 Prague, Czech Republic.
Cells. 2022 May 3;11(9):1525. doi: 10.3390/cells11091525.
Current understanding of the mechanisms underlying central nervous system (CNS) injury is limited, and traditional therapeutic methods lack a molecular approach either to prevent acute phase or secondary damage, or to support restorative mechanisms in the nervous tissue. microRNAs (miRNAs) are endogenous, non-coding RNA molecules that have recently been discovered as fundamental and post-transcriptional regulators of gene expression. The capacity of microRNAs to regulate the cell state and function through post-transcriptionally silencing hundreds of genes are being acknowledged as an important factor in the pathophysiology of both acute and chronic CNS injuries. In this study, we have summarized the knowledge concerning the pathophysiology of several neurological disorders, and the role of most canonical miRNAs in their development. We have focused on the miR-20, the miR-17~92 family to which miR-20 belongs, and their function in the normal development and disease of the CNS.
目前对中枢神经系统 (CNS) 损伤机制的认识有限，传统的治疗方法缺乏一种分子方法来预防急性期或继发性损伤，或支持神经组织的修复机制。microRNAs (miRNAs) 是内源性的非编码 RNA 分子，最近被发现是基因表达的基本和转录后调控因子。miRNAs 通过转录后沉默数百个基因来调节细胞状态和功能的能力被认为是急性和慢性 CNS 损伤病理生理学的一个重要因素。在这项研究中，我们总结了几种神经疾病的病理生理学知识，以及大多数经典 miRNA 在其发展中的作用。我们重点介绍了 miR-20 和属于它的 miR-17~92 家族，以及它们在 CNS 的正常发育和疾病中的功能。
