Department of Pathology, Chi-Mei Medical Center, Tainan, Taiwan; Department of Pathology, National Taiwan University, Taipei, Taiwan; Department of Pathology, Taipei Medical University, Taipei, Taiwan.
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Am Acad Dermatol. 2014 Apr;70(4):724-735. doi: 10.1016/j.jaad.2013.11.047. Epub 2014 Feb 9.
Mycosis fungoides is the prototype of primary cutaneous T-cell lymphoma and is more common in the West than in the East, whereas nonmycotic primary cutaneous T-cell lymphoma is more frequent than mycosis fungoides among Asians. Nonmycotic primary cutaneous T-cell lymphomas comprise several categories of neoplasms and might pose diagnostic challenges because of the rarity of these lesions and overlapping features among certain entities. The authors recommend diagnostic approaches including histopathological evaluation, immunohistochemical markers, and ancillary studies. Diagnostic dilemma in certain entities and cases with atypical clinicopathological features are discussed.
蕈样肉芽肿是原发性皮肤 T 细胞淋巴瘤的原型，在西方比在东方更为常见，而非蕈样肉芽肿的原发性皮肤 T 细胞淋巴瘤在亚洲人中比蕈样肉芽肿更为常见。非蕈样肉芽肿的原发性皮肤 T 细胞淋巴瘤包括几类肿瘤，由于这些病变罕见，并且某些实体之间存在重叠特征，因此可能具有诊断挑战。作者建议采用包括组织病理学评估、免疫组织化学标志物和辅助研究在内的诊断方法。讨论了某些实体和具有非典型临床病理特征的病例中的诊断难题。
