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[Prenatal pharmacology of low molecular weight heparin and pentosan polysulfate].

作者信息

Rainaut M, Forestier F, Daffos F, Fisher A M, Aiach M

机构信息

Centre de diagnostic prénatal, Hôpital Notre-Dame-du-Bon-Secours, Paris.

出版信息

J Mal Vasc. 1987;12 Suppl B:119-22.

PMID:2452225
Abstract

The aim of prenatal pharmacology is to evaluate the biologic effects to the fetus of a drug taken during pregnancy. Development of a new technic for collection of fetal blood samples in utero under ultrasound guidance allowed, by evaluation of maternal and fetal hemostasis, study of two low molecular weight heparins, PK 10169 (Lovenox) (table I) and CY 216 (Fraxiparine) (tableau II) and of pentosan polysulfate (Hemoclar) (table III). Under the operating conditions applied, the three molecules failed to diffuse across placenta during 2nd and 3rd pregnancy trimesters. This permitted treatment of eleven women at risk for eclampsia or thromboembolism with good clinical results, white confirming absence of circulating heparinemia at birth (umbilical cord blood).

摘要

相似文献

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[Prenatal pharmacology of low molecular weight heparin and pentosan polysulfate].
J Mal Vasc. 1987;12 Suppl B:119-22.
2
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Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro.戊聚糖多硫酸酯,一种硫酸化低聚糖,在体外是一种有效的选择性抗HIV药物。
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