默克尔细胞多瘤病毒的分子流行病学：地理相关变异基因型的证据
Molecular epidemiology of merkel cell polyomavirus: evidence for geographically related variant genotypes.
作者信息
Martel-Jantin Claire, Filippone Claudia, Tortevoye Patricia, Afonso Philippe V, Betsem Edouard, Descorps-Declere Stéphane, Nicol Jérôme T J, Touzé Antoine, Coursaget Pierre, Crouzat Maryse, Berthet Nicolas, Cassar Olivier, Gessain Antoine
机构信息
Institut Pasteur, Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie, Paris, France.
出版信息
J Clin Microbiol. 2014 May;52(5):1687-90. doi: 10.1128/JCM.02348-13. Epub 2014 Feb 12.
Abstract
Merkel cell polyomavirus (MCPyV) is linked to a cutaneous cancer mainly occurring in Caucasians. DNA from skin swabs of 255 adults, originating from the 5 continents, were subjected to MCPyV PCRs. Phylogenetic analyses demonstrate the existence of 5 major geographically related MCPyV genotypes (Europe/North America, Africa [sub-Saharan], Oceania, South America, and Asia/Japan).
摘要
默克尔细胞多瘤病毒（MCPyV）与一种主要发生在白种人的皮肤癌有关。对来自五大洲的255名成年人皮肤拭子中的DNA进行了MCPyV聚合酶链反应（PCR）检测。系统发育分析表明存在5种主要的与地理区域相关的MCPyV基因型（欧洲/北美洲、非洲[撒哈拉以南]、大洋洲、南美洲以及亚洲/日本）。
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