• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

某些新型（2E）-2-[1-芳基-3-（1H-咪唑-1-基）亚丙基]-N-（芳基/H）肼甲酰胺的抗惊厥潜力

Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.

作者信息

Attia Mohamed I, Aboul-Enein Mohamed N, El-Azzouny Aida A, Maklad Yousreya A, Ghabbour Hazem A

机构信息

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia ; Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.

Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.

出版信息

ScientificWorldJournal. 2014 Jan 12;2014:357403. doi: 10.1155/2014/357403. eCollection 2014.

DOI:10.1155/2014/357403
PMID:24523636
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3913509/
Abstract

Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a-p are reported. The test compounds 6a-p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μ mol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds 6a-p was confirmed via single crystal X-ray structure of compound 6g.

摘要

报道了某些含咪唑的新型芳基氨基脲6a-p的抗惊厥潜力和神经毒性。测试化合物6a-p主要在皮下注射戊四氮（scPTZ）筛选中表现出抗惊厥活性。化合物6p在scPTZ筛选中在636 μmol/kg的剂量水平下显示出100%的保护作用且无任何神经毒性，成为最具活性的替代物。通过化合物6g的单晶X射线结构确定了标题化合物6a-p的指定（E）-构型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/7e942a84cc54/TSWJ2014-357403.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/632cfa2d7c5c/TSWJ2014-357403.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/66364e99bf6e/TSWJ2014-357403.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/99df4978a1e4/TSWJ2014-357403.sch.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/7e942a84cc54/TSWJ2014-357403.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/632cfa2d7c5c/TSWJ2014-357403.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/66364e99bf6e/TSWJ2014-357403.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/99df4978a1e4/TSWJ2014-357403.sch.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/51dc/3913509/7e942a84cc54/TSWJ2014-357403.002.jpg

相似文献

1
Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.某些新型（2E）-2-[1-芳基-3-（1H-咪唑-1-基）亚丙基]-N-（芳基/H）肼甲酰胺的抗惊厥潜力
ScientificWorldJournal. 2014 Jan 12;2014:357403. doi: 10.1155/2014/357403. eCollection 2014.
2
Imidazole incorporated semicarbazone derivatives as a new class of anticonvulsants: design, synthesis and in-vivo screening.咪唑并缩氨基脲衍生物作为一类新型的抗惊厥药物：设计、合成与体内筛选。
Med Chem. 2013 Jun 1;9(4):571-80. doi: 10.2174/1573406411309040011.
3
N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: synthesis and anticonvulsant activity.N'-[(5-氯-3-甲基-1-苯基-1H-吡唑-4-基)亚甲基]-2/4-取代腙类化合物的合成及抗惊厥活性。
Eur J Med Chem. 2010 Sep;45(9):3943-9. doi: 10.1016/j.ejmech.2010.05.049. Epub 2010 Jun 1.
4
Synthesis and anticonvulsant evaluation of some novel (thio)semicarbazone derivatives of arylalkylimidazole.一些新型芳基烷基咪唑（硫代）缩氨基脲衍生物的合成与抗惊厥活性评价
Arzneimittelforschung. 2011;61(6):327-34.
5
Synthesis and anticonvulsant activity of some omega-(1H-1-imidazolyl)-N-phenylalkanoic acid amide derivatives.
Farmaco. 2002 Mar;57(3):201-6. doi: 10.1016/s0014-827x(01)01197-1.
6
Synthesis, anticonvulsant and toxicity evaluation of 2-(1H-indol-3-yl)acetyl-N-(substituted phenyl)hydrazine carbothioamides and their related heterocyclic derivatives.2-(1H-吲哚-3-基)乙酰基-N-(取代苯基)肼基硫代甲酰胺及其相关杂环衍生物的合成、抗惊厥活性及毒性评价
Acta Pharm. 2008 Dec;58(4):445-54. doi: 10.2478/v10007-008-0025-0.
7
Synthesis and Anticonvulsant Activity of Substituted-1,3-diazaspiro[4.5]decan-4-ones.取代-1,3-二氮杂螺[4.5]癸烷-4-酮的合成及抗惊厥活性。
Arch Pharm (Weinheim). 2015 Aug;348(8):575-88. doi: 10.1002/ardp.201500092. Epub 2015 May 29.
8
Design, synthesis and anticonvulsant activity of new imidazolidindione and imidazole derivatives.新型咪唑烷二酮和咪唑衍生物的设计、合成及抗惊厥活性。
Bioorg Chem. 2020 Aug;101:104020. doi: 10.1016/j.bioorg.2020.104020. Epub 2020 Jun 17.
9
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives.乙基 1-(2-芳基肼基甲酰胺基)-2,2-二甲基环丙甲酰胺衍生物的合成及抗惊厥活性。
Eur J Med Chem. 2012 Aug;54:542-8. doi: 10.1016/j.ejmech.2012.05.037. Epub 2012 Jun 6.
10
Synthesis, anticonvulsant and neurotoxicity screening of some novel 1,2,4-trisubstituted-1H-imidazole derivatives.一些新型1,2,4-三取代-1H-咪唑衍生物的合成、抗惊厥及神经毒性筛选
Acta Pol Pharm. 2011 Sep-Oct;68(5):657-63.

引用本文的文献

1
Chemical Composition and Antioxidant and Antibacterial Activities of an Essential Oil Extracted from an Edible Seaweed, Laminaria japonica L.从可食用海藻海带（Laminaria japonica L.）中提取的挥发油的化学成分、抗氧化及抗菌活性
Molecules. 2015 Jul 2;20(7):12093-113. doi: 10.3390/molecules200712093.

本文引用的文献

1
A novel antifungal agent with broad spectrum: 1-(4-biphenylyl)-3-(1H-imidazol-1-yl)-1-propanone.一种具有广谱抗真菌作用的新型化合物：1-(4-联苯基)-3-(1H-咪唑-1-基)-1-丙酮。
Arch Pharm (Weinheim). 2013 Feb;346(2):110-8. doi: 10.1002/ardp.201200287. Epub 2012 Dec 13.
2
1-{(E)-[3-(1H-Imidazol-1-yl)-1-phenyl-propyl-idene]amino}-3-(2-methyl-phen-yl)urea.1-{(E)-[3-(1H-咪唑-1-基)-1-苯基-亚丙基]氨基}-3-(2-甲基-苯基)脲
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1848-9. doi: 10.1107/S1600536812022659. Epub 2012 May 23.
3
1-{(E)-[3-(1H-Imidazol-1-yl)-1-(4-meth-oxy-phen-yl)propyl-idene]amino}-3-(2-methyl-phen-yl)urea.
1-{(E)-[3-(1H-咪唑-1-基)-1-(4-甲氧基苯基)亚丙基]氨基}-3-(2-甲基苯基)脲
Acta Crystallogr Sect E Struct Rep Online. 2012 Jun 1;68(Pt 6):o1799-800. doi: 10.1107/S1600536812021903. Epub 2012 May 19.
4
Design and synthesis of novel stiripentol analogues as potential anticonvulsants.新型司替戊醇类似物的设计与合成及其作为潜在抗惊厥药物的研究。
Eur J Med Chem. 2012 Jan;47(1):360-9. doi: 10.1016/j.ejmech.2011.11.004. Epub 2011 Nov 11.
5
Synthesis and anti-candida potential of certain novel 1-[(3-Substituted-3-phenyl)propyl]-1H-imidazoles.某些新型 1-[(3-取代-3-苯基)丙基]-1H-咪唑的合成及抗假丝酵母活性。
Arch Pharm (Weinheim). 2011 Dec;344(12):794-801. doi: 10.1002/ardp.201000224. Epub 2011 Oct 11.
6
Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.嘧啶脒腙衍生物的合成、抗惊厥和毒性筛选。
Eur J Med Chem. 2010 Jun;45(6):2467-72. doi: 10.1016/j.ejmech.2010.02.031. Epub 2010 Feb 18.
7
The prevalence of epilepsy and pharmacoresistant epilepsy in adults: a population-based study in a Western European country.成人癫痫和药物抵抗性癫痫的患病率：一项在西欧某国开展的基于人群的研究。
Epilepsia. 2008 Jul;49(7):1230-8. doi: 10.1111/j.1528-1167.2008.01579.x.
8
Idiosyncratic adverse reactions to antiepileptic drugs.抗癫痫药物的特异质性不良反应。
Epilepsia. 2007 Jul;48(7):1223-44. doi: 10.1111/j.1528-1167.2007.01041.x. Epub 2007 Mar 26.
9
7-Nitroindazole potentiates the anticonvulsant action of some second-generation antiepileptic drugs in the mouse maximal electroshock-induced seizure model.7-硝基吲唑在小鼠最大电休克诱导癫痫模型中增强了一些第二代抗癫痫药物的抗惊厥作用。
J Neural Transm (Vienna). 2006 Sep;113(9):1157-68. doi: 10.1007/s00702-005-0417-y. Epub 2006 Feb 9.
10
A note on a simple apparatus for detecting neurological deficit in rats and mice.关于一种用于检测大鼠和小鼠神经功能缺损的简易装置的说明。
J Am Pharm Assoc Am Pharm Assoc. 1957 Mar;46(3):208-9. doi: 10.1002/jps.3030460322.