Nishiyama K, Nishida K, Kusaka K, Morizumi H
Department of Neurological Surgery, Tokushima Municipal Hospital, Japan.
No Shinkei Geka. 1987 Dec;15(12):1337-42.
A case of primary suprasellar germ cell tumor that produced alpha-fetoprotein (AFP) and human chorionic gonadotropin (HCG) in a 8-year-old boy is reported. Partial removal of tumor and combination chemotherapy using cisplatin, vincristine, and bleomycin (modified PVB therapy) resulted in an almost definite regression of the tumor and improvement from clinical symptoms in this case. After the chemotherapy the concentrations of both serum AFP and serum HCG decreased to normal levels as well. Moreover by the immunoperoxidase method AFP, HCG, and placental alkaline phosphatase were found in this particular tumor tissue. In reviewing previous reports the immunohistochemical demonstration of three tumor markers in a single germ cell tumor is seemed to be extremely rare.
报告了一例8岁男孩原发性鞍上生殖细胞瘤，该肿瘤产生甲胎蛋白（AFP）和人绒毛膜促性腺激素（HCG）。肿瘤部分切除并使用顺铂、长春新碱和博来霉素进行联合化疗（改良PVB疗法），使该病例的肿瘤几乎完全消退，临床症状改善。化疗后，血清AFP和血清HCG浓度也降至正常水平。此外，通过免疫过氧化物酶法在该特定肿瘤组织中发现了AFP、HCG和胎盘碱性磷酸酶。回顾以往报告，单个生殖细胞瘤中三种肿瘤标志物的免疫组化显示似乎极为罕见。
