萘普生在新型碳纳米管水凝胶递送系统中的缓释。
Sustained release of naproxen in a new kind delivery system of carbon nanotubes hydrogel.
作者信息
Peng Xiahui, Zhuang Qiang, Peng Dongming, Dong Qiuli, Tan Lini, Jiao Feipeng, Liu Linqi, Liu Jingyu, Zhao Chenxi, Wang Xiaomei
机构信息
Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.
School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
出版信息
Iran J Pharm Res. 2013 Fall;12(4):581-6.
In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.
在本文中，碳纳米管（CNTs）以壳聚糖改性碳纳米管（CS-CNTs）复合材料的形式添加到壳聚糖（CS）水凝胶中，以制备碳纳米管水凝胶（CNTs-GEL）。将所得产物命名为CS-MWCNTs，通过扫描电子显微镜（SEM）和傅里叶变换红外（FTIR）光谱对其进行表征。分别研究了两种水凝胶，即CNTs-GEL和不含CNTs的纯壳聚糖水凝胶（GEL）的溶胀性能以及pH对其控释性能的影响。结果表明，CNTs-GEL比GEL具有更好的控释性能。在pH = 7.4和pH = 1.2条件下，CNTs-GEL的释放平衡时间均长于GEL，尽管在相同pH缓冲溶液中模型药物的释放率相似。研究发现，释放动力学在pH = 1.2时更符合Ritger-Peppas经验模型，表明为菲克扩散过程，而在pH = 7.4时为非菲克扩散，涉及表面扩散和腐蚀扩散过程。
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