Höhne Susanne, Frenzel Ralf, Heppe Andreas, Simon Frank
Leibniz Institute of Polymer Research Dresden, Hohe Strasse 6, Dresden, Germany.
Biomacromolecules. 2007 Jul;8(7):2051-8. doi: 10.1021/bm0702354. Epub 2007 Jun 15.
Hydrophobically modified chitosan microparticles were produced by various syntheses carried out as heterogeneous phase reactions. Perfluorinated carbonyl components such as carbonic acids and acid chlorides were used as hydrophobization agents. To enhance the layer stability preceding cross-linkages between the chitosan macromolecules were introduced. These cross-linkages involve some of the chitosan amino groups. The use of a highly reactive alkylene-maleic anhydride copolymer produces cross-linkages and hydrophobizes the chitosan layer simultaneously in a one-step reaction. The heterogeneous reactions serve as model reactions for the hydrophobization of chitosan films deposited on supports.
疏水性改性壳聚糖微粒是通过作为多相反应进行的各种合成方法制备的。全氟羰基化合物如碳酸和酰氯被用作疏水化剂。为了提高壳聚糖大分子之间交联前的层稳定性，引入了一些交联。这些交联涉及壳聚糖的一些氨基。使用高反应性的亚烷基-马来酸酐共聚物在一步反应中同时产生交联并使壳聚糖层疏水化。这些多相反应作为沉积在载体上的壳聚糖膜疏水化的模型反应。
