Bjurholm A, Kreicbergs A, Brodin E, Schultzberg M
Department of Orthopaedic Surgery, Karolinska Hospital, Stockholm, Sweden.
Peptides. 1988 Jan-Feb;9(1):165-71. doi: 10.1016/0196-9781(88)90023-x.
The present study demonstrates the occurrence of substance P (SP)- and calcitonin gene related peptide (CGRP)-immunoreactive nerve fibres in bone, bone marrow, periosteum, synovial membrane and soft tissues adjacent to the bone. The distribution pattern of the two types of nerves was similar, although the CGRP-positive fibres generally were more numerous. Both types of nerves were particularly abundant near the epiphyseal plate, in the bone marrow of patella and epiphyses, and in the periosteum. Many SP- and CGRP-immunoreactive fibres were also observed around blood vessels.
本研究证实了在骨、骨髓、骨膜、滑膜以及骨周围的软组织中存在P物质（SP）和降钙素基因相关肽（CGRP）免疫反应性神经纤维。尽管CGRP阳性纤维通常数量更多，但两种类型神经的分布模式相似。这两种神经在骨骺板附近、髌骨和骨骺的骨髓以及骨膜中特别丰富。在血管周围也观察到许多SP和CGRP免疫反应性纤维。
