芦丁对丙烯酰胺诱导的神经毒性的影响。

Effects of rutin on acrylamide-induced neurotoxicity.

机构信息

Pharmacodynamics and Toxicological Department, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Daru. 2014 Feb 13;22(1):27. doi: 10.1186/2008-2231-22-27.

BACKGROUND

Rutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied.

RESULTS

Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).

CONCLUSION

It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

背景

芦丁是一种重要的类黄酮，在日常饮食中被摄入。芦丁具有抗氧化和神经保护作用，已在多项研究中得到证实。丙烯酰胺（ACR）对人类和动物具有神经毒性作用。在这项研究中，研究了芦丁在预防和治疗 ACR 神经毒性中的作用。

结果

芦丁以时间和剂量依赖的方式显著降低了 ACR（5.46 mM）诱导的细胞死亡。与对照组相比，芦丁处理显著降低了 ACR 诱导的细胞毒性（P<0.01，P<0.001）。芦丁（100 和 200 mg/kg）可预防大鼠体重下降。在与芦丁（50、100 和 200 mg/kg）联合治疗的组合中，步态异常以剂量依赖性方式显著减少（P<0.01 和 P<0.001）。接受芦丁（100 和 200 mg/kg）预防和治疗的大鼠脑组织中丙二醛水平显著降低。