Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Iran.
Epilepsy Behav. 2010 May;18(1-2):50-3. doi: 10.1016/j.yebeh.2010.03.005. Epub 2010 May 10.
Individuals with epilepsy often complain about memory deficits. Various synthetic derivatives of natural flavonoids are known to have neuroactive properties. Rutin is a flavonoid that is an important dietary constituent of foods and plant-based beverages. The aim of the present study was to investigate the effects of rutin on memory retrieval in pentylenetetrazole (PTZ)-kindled rats using a step-through passive avoidance task. We administered rutin and PTZ intraperitoneally every other day prior to the start of training. Two retention tests were subsequently performed to assess memory in these rats. The results suggest that pretreatment with rutin at 50 and 100mg/kg can attenuate seizure severity during the kindling procedure. Furthermore, rutin administration significantly increased the step-through latency in the passive avoidance paradigm. Taken together, these results indicate that rutin has a potential role in enhancing memory retrieval in kindled rats.
患有癫痫的个体常抱怨记忆力减退。已知多种天然类黄酮的合成衍生物具有神经活性。芦丁是一种类黄酮，是食物和植物性饮料的重要膳食成分。本研究的目的是使用穿梭式被动回避任务来研究芦丁对戊四氮（PTZ）点燃大鼠记忆检索的影响。我们在训练开始前每隔一天腹膜内给予芦丁和 PTZ。随后进行了两次保留测试，以评估这些大鼠的记忆。结果表明，芦丁预处理 50 和 100mg/kg 可减轻点燃过程中的癫痫严重程度。此外，芦丁给药显著增加了被动回避范式中的潜伏期。总之，这些结果表明芦丁在增强点燃大鼠的记忆检索方面具有潜在作用。
