Fleiss Bobbi, Guillot Pascale V, Titomanlio Luigi, Baud Olivier, Hagberg Henrik, Gressens Pierre
Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France; Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK.
UCL Institute for Women's Health, University College London, London, WC1E 6HX, UK.
Clin Perinatol. 2014 Mar;41(1):133-48. doi: 10.1016/j.clp.2013.09.002. Epub 2013 Dec 12.
This article introduces the basic concepts of modeling neonatal brain injury and provides background information regarding each of the commonly used types of stem cells. It summarizes the findings of preclinical research testing the therapeutic potential of stem cells in animal models of neonatal brain injury, reports briefly on the status of clinical trials, and discusses the important ongoing issues that need to be addressed before stem cell therapy is used to repair the injured brain.
本文介绍了新生儿脑损伤建模的基本概念，并提供了有关每种常用干细胞类型的背景信息。它总结了在新生儿脑损伤动物模型中测试干细胞治疗潜力的临床前研究结果，简要报告了临床试验的现状，并讨论了在使用干细胞疗法修复受损大脑之前需要解决的重要的当前问题。
