Mood Disorders Unit, Aarhus University Hospital, Skovagervej 2, 8240 Risskov, Denmark.
Mood Disorders Unit, Aarhus University Hospital, Skovagervej 2, 8240 Risskov, Denmark.
Psychiatry Res. 2014 Apr 30;216(1):37-43. doi: 10.1016/j.psychres.2013.12.010. Epub 2013 Dec 14.
Patients suffering from major depression experience difficulties in multiple cognitive faculties. A growing body of research has linked affective disorders to abnormalities in social cognition and specifically the processing of discrete emotional stimuli. However, little inquiry has gone into possible impairment in higher-order social cognition including theory of mind, social perception and metacognition. Forty-four medication-naïve patients with first-episode unipolar major depressive disorder and an equal number of matched controls were assessed by the Metacognitive Assessment Scale-Abbreviated (MAS-A), The Frith-Happé animations (FHA) and The Awareness of Social Inference Test (TASIT). Additionally, neurocognition was assessed utilyzing the Cambridge Neuropsychological Test Automated Battery (CANTAB). Depressed patients showed impairment in all domains of higher-order social cognitive ability. Importantly, social cognitive variables retained their inter-group significance after controlling for possible covariates including neurocognition. Results indicate that first-episode depressed patients experience difficulties in all domains of higher-order social cognition including theory of mind, social perception and metacognition.
患有重度抑郁症的患者在多种认知能力上都存在困难。越来越多的研究将情感障碍与社会认知异常联系起来，特别是与离散情绪刺激的处理有关。然而，对于包括心理理论、社会感知和元认知在内的更高层次的社会认知可能存在的损害，几乎没有进行调查。44 名首次发作的单相重度抑郁症的未经药物治疗的患者和数量相等的匹配对照组接受了元认知评估量表-简化版（MAS-A）、弗里思-哈佩动画（FHA）和社会推理意识测验（TASIT）的评估。此外，还利用剑桥神经心理学测试自动电池（CANTAB）评估了神经认知。抑郁患者在所有高级社会认知能力领域都表现出障碍。重要的是，在控制可能的协变量（包括神经认知）后，社会认知变量仍然保持着组间的显著性。结果表明，首发抑郁患者在心理理论、社会感知和元认知等所有高级社会认知领域都存在困难。
