用于光电化学检测葡萄糖和癌细胞的低毒 Ag2S 量子点。
Low-toxic Ag2S quantum dots for photoelectrochemical detection glucose and cancer cells.
机构信息
Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China.
Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, PR China; Key Laboratory of Detection Technology of Shandong Province for Tumor Marker, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, PR China.
出版信息
Biosens Bioelectron. 2014 Jun 15;56:307-12. doi: 10.1016/j.bios.2014.01.033. Epub 2014 Jan 23.
A new photoelectrochemical (PEC) biosensor was developed using low-toxic Ag2S QDs as photoelectrochemically active species. Energy levels of Ag2S and Ag2Se QD were compared to explain their differences in the PEC performance. The preparation condition of Ag2S QD was optimized and its structure characterization was measured. Then the developed photoelectric active interface was used to detect glucose and MCF-7 cancer cell and showed the good sensitivity and specificity. Under optimal condition, detection limits of 3.2 × 10(-5)M for glucose and 98 cells/mL for MCF-7 cell were achieved. Thus, the prepared Ag2S QD could serve as an excellent and promising photoelectric active material in the PEC biosensor.
采用低毒的 Ag2S QD 作为光电活性物质，研制了一种新的光电化学（PEC）生物传感器。比较了 Ag2S 和 Ag2Se QD 的能级，以解释它们在 PEC 性能上的差异。优化了 Ag2S QD 的制备条件，并对其结构特征进行了测量。然后，将开发的光电活性界面用于检测葡萄糖和 MCF-7 癌细胞，并表现出良好的灵敏度和特异性。在最佳条件下，葡萄糖的检测限为 3.2×10(-5)M，MCF-7 细胞的检测限为 98 个细胞/mL。因此，所制备的 Ag2S QD 可用作 PEC 生物传感器中一种优异且有前途的光电活性材料。
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