College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.
Biosensors (Basel). 2021 Aug 18;11(8):281. doi: 10.3390/bios11080281.
The accurate analysis of circulating tumor cells (CTCs) holds great promise in early diagnosis and prognosis of cancers. However, the extremely low abundance of CTCs in peripheral blood samples limits the practical utility of the traditional methods for CTCs detection. Thus, novel and powerful strategies have been proposed for sensitive detection of CTCs. In particular, nanomaterials with exceptional physical and chemical properties have been used to fabricate cytosensors for amplifying the signal and enhancing the sensitivity. In this review, we summarize the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, including fluorescence, colorimetry, surface-enhanced Raman scattering, chemiluminescence, electrochemistry, electrochemiluminescence, photoelectrochemistry and so on.
循环肿瘤细胞（CTC）的准确分析在癌症的早期诊断和预后中具有巨大的应用前景。然而，外周血样本中 CTC 的含量极低，限制了传统 CTC 检测方法的实际应用。因此，人们提出了新的强大策略来敏感地检测 CTC。特别是，具有优异物理和化学性质的纳米材料已被用于制造细胞传感器，以放大信号并提高灵敏度。在这篇综述中，我们总结了基于纳米材料的光学和电化学分析技术在 CTC 检测方面的最新进展，包括荧光、比色法、表面增强拉曼散射、化学发光、电化学、电致化学发光、光电化学等。
