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胰十二指肠切除术后行空肠置管喂养与较高的发病率相关。

Feeding jejunostomy during Whipple is associated with increased morbidity.

机构信息

Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Department of Surgery, Duke University Medical Center, Durham, North Carolina.

出版信息

J Surg Res. 2014 Apr;187(2):361-6. doi: 10.1016/j.jss.2012.10.010. Epub 2012 Oct 25.

Abstract

BACKGROUND

Placement of a feeding jejunostomy tube (FJ) is often performed during pancreaticoduodenectomy (PD). Few studies, however, have sought to determine whether such placement affects postoperative outcomes after PD.

MATERIALS AND METHODS

This is a retrospective analysis of the National Surgical Quality Improvement Program (NSQIP) database to determine the 30-d-postoperative mortality rate, major complication rate, and overall complication rate of jejunostomy tube placement at the time of PD. Univariate and multivariate comparison of postoperative outcomes between patients with and without FJ placement during PD was performed on a total of 4930 patients.

RESULTS

Thirty-day-postoperative mortality did not differ between the two groups (4.0% for patients with FJ versus 2.7% without, P = 0.13), whereas overall morbidity (43.3% with FJ versus 34.6% without, P < 0.0001) and serious morbidity (29.5% with FJ versus 22.8% without, P < 0.0001) were significantly higher in patients undergoing FJ placement during PD. The specific complications that occurred more frequently in FJ patients than patients without FJ included deep space surgical site infection, pneumonia, unplanned reintubation, acute renal failure, and sepsis.

CONCLUSION

Although FJ placement during PD is considered to be routine at many institutions, our analysis of data from NSQIP suggest that FJ placement may be associated with increased postoperative morbidity.

摘要

背景

在胰十二指肠切除术(PD)期间,常进行饲管空肠造口术(FJ)置管。然而,很少有研究试图确定 PD 后这种置管是否会影响术后结果。

材料与方法

这是对国家手术质量改进计划(NSQIP)数据库的回顾性分析,旨在确定 PD 时 FJ 置管的 30 天术后死亡率、主要并发症率和总体并发症率。对总共 4930 例患者进行了 PD 期间有无 FJ 置管的术后结局的单变量和多变量比较。

结果

两组患者的 30 天术后死亡率无差异(有 FJ 的患者为 4.0%,无 FJ 的患者为 2.7%,P=0.13),但总体发病率(有 FJ 的患者为 43.3%,无 FJ 的患者为 34.6%,P<0.0001)和严重发病率(有 FJ 的患者为 29.5%,无 FJ 的患者为 22.8%,P<0.0001)在 PD 期间行 FJ 置管的患者中显著更高。FJ 患者比无 FJ 患者更常发生的特定并发症包括深部手术部位感染、肺炎、计划外重新插管、急性肾衰竭和败血症。

结论

尽管在许多机构中,PD 期间 FJ 置管被认为是常规操作,但我们对 NSQIP 数据的分析表明,FJ 置管可能与术后发病率增加相关。

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