Department of Natural Sciences; Lebanese American University; Beirut, Lebanon.
Cell Adh Migr. 2014;8(1):29-35. doi: 10.4161/cam.28024. Epub 2013 Jan 1.
Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane of motile cells undergoes highly regulated protrusions. Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines. Palladin regulates actin cytoskeleton organization as well as cell adhesion formation. Moreover, palladin contributes to the invasive nature of cancer metastatic cells by regulating invadopodia formation. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis.
细胞迁移和入侵涉及细胞黏附结构的形成，以及细胞骨架的动态和空间调节。被称为 podosomes 和 invadopodia 的黏附结构在细胞运动、黏附和入侵中发挥共同作用，并且在运动细胞的质膜发生高度调节的突起时形成。palladin 是一种分子支架，与富含肌动蛋白的结构共定位，在多种细胞系中发挥作用，调节它们的组装和维持。palladin 调节肌动蛋白细胞骨架组织以及细胞黏附的形成。此外，palladin 通过调节侵袭小体的形成，促进癌症转移细胞的侵袭特性。palladin 似乎通过 Rho GTPases 调节 podosome 和 invodopodia 的形成，Rho GTPases 是协调细胞迁移和转移所需的细胞反应的关键参与者。
