Jiang Xin, Qin Yiming, Kun Liu, Zhou Yanhong
NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, China.
Front Oncol. 2021 Mar 17;11:620390. doi: 10.3389/fonc.2021.620390. eCollection 2021.
Actin is the structural protein of microfilaments, and it usually exists in two forms: monomer and polymer. Among them, monomer actin is a spherical molecule composed of a polypeptide chain, also known as spherical actin. The function of actin polymers is to produce actin filaments, so it is also called fibroactin. The actin cytoskeleton is considered to be an important subcellular filament system. It interacts with numerous relevant proteins and regulatory cells, regulating basic functions, from cell division and muscle contraction to cell movement and ensuring tissue integrity. The dynamic reorganization of the actin cytoskeleton has immense influence on the progression and metastasis of cancer as well. This paper explores the significance of the microfilament network, the dynamic changes of its structure and function in the presence of a tumor, the formation process around the actin system, and the relevant proteins that may be target molecules for anticancer drugs so as to provide support and reference for interlinked cancer treatment research in the future.
肌动蛋白是微丝的结构蛋白，通常以两种形式存在：单体和聚合物。其中，单体肌动蛋白是由一条多肽链组成的球状分子，也称为球状肌动蛋白。肌动蛋白聚合物的功能是产生肌动蛋白丝，因此也称为纤维状肌动蛋白。肌动蛋白细胞骨架被认为是一种重要的亚细胞丝状系统。它与众多相关蛋白质和调节细胞相互作用，调节从细胞分裂、肌肉收缩到细胞运动等基本功能，并确保组织完整性。肌动蛋白细胞骨架的动态重组对癌症的进展和转移也有巨大影响。本文探讨了微丝网络的意义、其在肿瘤存在时结构和功能的动态变化、肌动蛋白系统周围的形成过程以及可能作为抗癌药物靶分子的相关蛋白质，以便为未来相互关联的癌症治疗研究提供支持和参考。
