Şahingöz Mine, Yuksel Goksen, Karsidag Cagatay, Uguz Faruk, Sonmez Erdem Onder, Annagur Bilge Burcak, Annagur Ali
From the *Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya; †Department of Psychiatry, Bakirkoy Research and Training Hospital, Istanbul; and Departments of ‡Psychiatry and §Neonatology, University of Selcuk, Faculty of Medicine, Konya, Turkey.
J Clin Psychopharmacol. 2014 Apr;34(2):226-9. doi: 10.1097/JCP.0000000000000077.
It is unclear whether antidepressant treatment has a preventive effect on negative neonatal outcomes due to major depression in pregnant women. The objective of the present study was to compare women with major depression treated with antidepressants, untreated women with major depression, and healthy women during pregnancy with respect to birth weight and preterm birth.
The study sample included a total of 23 women taking antidepressant medication, 36 women who were not taking antidepressant medication for major depression during pregnancy, and 30 healthy women. Major depression was diagnosed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.
The study groups were similar with respect to sociodemographic characteristics. Compared with infants of healthy control subjects, infants of untreated major depressed women had significantly lower birth weight and shorter gestational age at delivery. There is no significant difference between infants of major depressed women treated with antidepressants and infants of healthy subjects for these variables.
Our results suggest that antidepressants may have beneficial effects on the risk of low birth weight and preterm birth in the infants of depressed women.
目前尚不清楚抗抑郁治疗对孕妇重度抑郁症所致不良新生儿结局是否具有预防作用。本研究的目的是比较孕期服用抗抑郁药的重度抑郁症女性、未治疗的重度抑郁症女性和健康女性在出生体重和早产方面的情况。
研究样本共包括23名服用抗抑郁药物的女性、36名孕期未因重度抑郁症服用抗抑郁药物的女性以及30名健康女性。重度抑郁症通过《精神障碍诊断与统计手册》第四版的结构化临床访谈进行诊断。
研究组在社会人口学特征方面相似。与健康对照受试者的婴儿相比，未治疗的重度抑郁症女性的婴儿出生体重显著更低，分娩时孕周更短。对于这些变量，服用抗抑郁药的重度抑郁症女性的婴儿与健康受试者的婴儿之间无显著差异。
我们的结果表明，抗抑郁药可能对抑郁症女性婴儿的低出生体重和早产风险具有有益影响。
