[孕期抑郁与新生儿低出生体重之间的关联：一项Meta分析]
[Association between depression during pregnancy and low birth weight in neonates: a Meta analysis].
作者信息
Liu Yi, Zhuo Lin, Zhu Bei, He Ming-Yu, Xu Yang, Wang Tong-Tong, Hu Bin, Xu Ji-Cheng
机构信息
School of Public Health of Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Sep;19(9):994-998. doi: 10.7499/j.issn.1008-8830.2017.09.012.
OBJECTIVE
To study the association between depression during pregnancy and low birth weight in neonates, and to provide a scientific basis for the prevention of low birth weight.
METHODS
Cohort studies on the association between depression during pregnancy and low birth weight were collected and a Meta analysis was performed. Data were extracted independently by two investigators, and quality assessment was performed according to Newcastle-Ottawa Scale. The Egger's test was used to evaluate publication bias.
RESULTS
A total of 12 cohort studies with 37 192 samples were included. The results of the Meta analysis showed that depression during pregnancy was associated with low birth weight (Z=2.08, P=0.038), and the neonates whose mothers had depression during pregnancy tended to have a high risk of low birth weight (RR=1.303, 95%CI: 1.015-1.672). The sensitivity analysis showed that the results of this Meta analysis were stable and reliable, and the Egger's test showed no publication bias.
CONCLUSIONS
Depression during pregnancy may be a risk factor for low birth weight in neonates.
目的
研究孕期抑郁与新生儿低出生体重之间的关联，为预防低出生体重提供科学依据。
方法
收集关于孕期抑郁与低出生体重关联的队列研究并进行Meta分析。由两名研究者独立提取数据，并根据纽卡斯尔-渥太华量表进行质量评估。采用Egger检验评估发表偏倚。
结果
共纳入12项队列研究，样本量为37192例。Meta分析结果显示，孕期抑郁与低出生体重有关联（Z=2.08，P=0.038），孕期母亲有抑郁的新生儿发生低出生体重的风险较高（RR=1.303，95%CI：1.015-1.672）。敏感性分析表明该Meta分析结果稳定可靠，Egger检验显示无发表偏倚。
结论
孕期抑郁可能是新生儿低出生体重的一个危险因素。
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