Alipour Sadaf, Hadji Maryam, Hosseini Ladan, Omranipour Ramesh, Saberi Azin, Seifollahi Akram, Bayani Leila, Shirzad Nooshin
Department of Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran E-mail :
Asian Pac J Cancer Prev. 2014;15(1):129-32. doi: 10.7314/apjcp.2014.15.1.129.
The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses and controls.
Levels of vitamin D were measured by electrochemiluminescense. Serum levels >35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severe vitamin D deficiency, respectively.
Overall, 364 women were included in the control, 172 in the benign and 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancers than controls. Levels were also lower in malignant than benign cases and in benign cases than controls although statistically non-significant.
Multinomial logistic regression analysis showed that severe vitamin D deficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate and mild deficiency.
乳腺癌与维生素D之间的真正关联目前正在研究中。我们比较了患有良性和恶性乳腺肿块的女性以及对照组的血清25-羟基维生素D水平。
采用电化学发光法测定维生素D水平。血清水平>35 ng/ml、25-35 ng/ml、12.5-25 ng/ml和<12.5 ng/ml分别被视为正常、轻度、中度和重度维生素D缺乏。
总体而言，对照组纳入364名女性，良性组172名，恶性组136名。乳腺癌患者的血清维生素D中位数水平显著低于对照组。恶性组水平也低于良性组，良性组低于对照组，尽管在统计学上无显著差异。
多项逻辑回归分析表明，严重维生素D缺乏会使患乳腺癌的风险增加两倍，而中度和轻度缺乏则不然。
