Lello Stefano, Capozzi Anna, Scardina Lorenzo, Ionta Lucia, Sorge Roberto, Scambia Giovanni, Franceschini Gianluca
Department of Woman and Child Health and Public Health, Institute of Obstetrics and Gynecology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Department of Woman and Child Health and Public Health, Division of Breast Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
J Pers Med. 2022 Mar 14;12(3):465. doi: 10.3390/jpm12030465.
Background: Vitamin D (vitD) may be involved in different extraskeletal conditions as well as skeletal muscle diseases. It has been hypothesized that, at least in part, a low level of vitD could contribute to facilitating cancer development. Breast cancer (BC) seems to be associated with low levels of vitD. Materials and methods: This was an observational retrospective evaluation of 87 women (mean age: 54 ± 12 years old) who underwent surgery for the treatment of BC. Our main purpose was to correlate the types of BC and the levels of vitD. Results: A positive significant correlation (R > 0.7) was found between non-invasive carcinoma in situ and 25(OH)D levels and age (R = 0.82, p < 0.05). A positive, but nonsignificant, correlation was reported between invasive ductal carcinoma and 25(OH)D and age (R = 0.45, p > 0.05). A negative but nonsignificant correlation was found between invasive lobular carcinoma and 25(OH)D and age (R = 0.24, p > 0.05). Discussion and Conclusions: We did not find a significant relationship between vitD and BC subtypes. Considering the positive significant correlation between vitD levels and age for in situ BC, although preliminary, our results seem to suggest a possible role of vitD in in situ BC. However, these findings need to be confirmed in larger studies.
维生素D（vitD）可能与不同的骨骼外疾病以及骨骼肌疾病有关。据推测，至少在一定程度上，低水平的vitD可能有助于促进癌症发展。乳腺癌（BC）似乎与低水平的vitD有关。材料与方法：这是一项对87名接受BC手术治疗的女性（平均年龄：54±12岁）进行的观察性回顾性评估。我们的主要目的是将BC的类型与vitD水平相关联。结果：原位非浸润性癌与25（OH）D水平及年龄之间存在显著正相关（R>0.7）（R = 0.82，p<0.05）。浸润性导管癌与25（OH）D及年龄之间存在正相关，但无统计学意义（R = 0.45，p>0.05）。浸润性小叶癌与25（OH）D及年龄之间存在负相关，但无统计学意义（R = 0.24，p>0.05）。讨论与结论：我们未发现vitD与BC亚型之间存在显著关系。考虑到原位BC中vitD水平与年龄之间存在显著正相关，尽管是初步的，但我们的结果似乎表明vitD在原位BC中可能发挥作用。然而，这些发现需要在更大规模的研究中得到证实。
