Li Ying-Jun, Zhang Zhen-Yu, Mao Ying-Ying, Jin Ming-Juan, Jing Fang-Yuan, Ye Zhen-Hua, Chen Kun
Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, China E-mail :
Asian Pac J Cancer Prev. 2014;15(1):145-50. doi: 10.7314/apjcp.2014.15.1.145.
MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83- 0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.
微小RNA（miRNA）通过负向调控基因表达，在肿瘤发生过程中发挥肿瘤抑制因子或癌基因的作用。以往研究中，miR-146a rs2910164单核苷酸多态性（SNP）与消化系统癌症易感性之间的关联并不一致。在本研究中，我们检索了PubMed数据库，以查找2013年8月31日前发表的所有相关研究。本项更新的荟萃分析共纳入21项独立的病例对照研究，包括9558例病例和10614例对照。我们发现，在等位基因模型（OR=0.90，95%CI 0.87 - 0.94）、纯合子模型（OR=0.84，95%CI 0.77 - 0.91）、显性模型（OR=0.90，95%CI 0.84 - 0.96）和隐性模型（OR=0.85，95%CI 0.79 - 0.91）中，miR-146a rs2910164多态性与消化系统癌症风险降低显著相关，而在杂合子模型（OR = 0.99，95%CI 0.89 - 1.11）中，该关联显示出边际显著性。按癌症部位进行的亚组分析显示，在等位基因模型（OR=0.90，95%CI 0.83 - 0.97）和纯合子模型（OR=0.85，95%CI 0.72 - 1.00）中，结直肠癌风险降低。同样，在胃癌中，与等位基因模型（OR=0.87，95%CI 0.81 - 0.93）和隐性模型（OR=0.81，95%CI 0.72 - 0.90）相比，癌症风险也降低。按种族、基因分型方法和质量评分进行分层时，也观察到癌症风险降低。当前的这项荟萃分析表明，miR-146a rs2910164多态性可能会降低消化系统癌症的易感性，尤其是在亚洲人群中。
