Xiong Xin, Yan Junfeng, Li Linghua, Li Yun, Cao Yi, Tu Yi, Mei Jinhong
The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Jiu Jiang No.1 People's Hospital, Jiujiang, Jiangxi, People's Republic of China.
Ann Clin Lab Sci. 2017 Aug;47(4):491-500.
MicroRNAs (miRNAs) are identified negatively regulating gene expression and acting as oncogenes or tumor suppressors in tumorigenesis. The association between miR-146a rs2910164 (G>C) polymorphism and susceptibility to digestive system cancers was contradictory and inconsistent in previously published studies. Presently, we performed a comprehensive literature retrieve on PubMed, Web of Science, Embase, Wanfang and CNKI databases to identify all relevant studies published before July 30, 2016. Odds ratio (OR) and 95% confidential interval (95%CI) were used to calculate the relationship between miR-146a rs2910164 (G>C) polymorphism and digestive system cancers susceptibility. Finally, a total of 45 publications comprising 47 separate case-control studies were enrolled in the present updated meta-analysis including 20,281 cases and 26,099 controls. However, no significant association was uncovered for miR-146a rs2910164 polymorphism and digestive system cancers susceptibility in all the genetic models. Moreover, in the stratification analyses by cancer type, the source of control, ethnicity and Hardy-Weinberg Equilibrium (HWE) status, we also revealed a negative result. To conclude, our work suggests that miR-146a rs2910164 (G>C) polymorphism is not a susceptibility factor for digestive system cancers.
微小RNA（miRNA）被认为在肿瘤发生过程中负向调控基因表达，并作为癌基因或肿瘤抑制因子发挥作用。在先前发表的研究中，miR-146a rs2910164（G>C）多态性与消化系统癌症易感性之间的关联相互矛盾且不一致。目前，我们在PubMed、Web of Science、Embase、万方和知网数据库中进行了全面的文献检索，以识别2016年7月30日前发表的所有相关研究。采用比值比（OR）和95%置信区间（95%CI）来计算miR-146a rs2910164（G>C）多态性与消化系统癌症易感性之间的关系。最终，本项更新的荟萃分析共纳入45篇文献，包括47项独立的病例对照研究，涵盖20281例病例和26099例对照。然而，在所有遗传模型中均未发现miR-146a rs2910164多态性与消化系统癌症易感性之间存在显著关联。此外，在按癌症类型、对照来源、种族和哈迪-温伯格平衡（HWE）状态进行的分层分析中，我们也得到了阴性结果。综上所述，我们的研究表明miR-146a rs2910164（G>C）多态性不是消化系统癌症的易感性因素。
