Seker Mehmet Metin, Kos Tugba, Ozdemir Nuriye, Seker Ayse, Aksoy Sercan, Uncu Dogan, Zengin Nurullah
Department of Medical Oncology, Cumhuriyet University Medical Faculty, Sivas, Turkey E-mail :
Asian Pac J Cancer Prev. 2014;15(1):327-30. doi: 10.7314/apjcp.2014.15.1.327.
Ewing sarcoma is a small round cell tumor arising from soft tissue and bone that predominantly affects children and adolescents. The most unfavorable prognostic factor is the presence of distant metastasis at the time of diagnosis.
The records of 26 Ewing sarcoma patients (14 male, 12 female) were re-evaluated retrospectively.
The median age was 26.5 (19-42) years. Eight patients (31%) showed a primary tumor in their extremities, 8 (31%) in the thorax, 4 (15%) at the vertebra, 4 (15%) in the head and neck, and 2 (8%) in the abdomen. Five patients (19%) had distant metastasis at diagnosis. The median progression-free survival was 72 months and 10 months in localized and metastatic disease, respectively (p=0.005). The overall survival rate was 19 months in metastatic disease, and the 5-year overall survival rate was 64% in localized disease (p=0.006). Patients who had localized disease in the extremities and were under age 30 had a favorable prognosis.
Although Ewing sarcoma is a tumor affecting children and adolescents, it may be seen in adults, where the prognosis is generally worse. Although it is a highly malignant tumor, it is possible to achieve improved survival with combined modality treatments.
尤因肉瘤是一种起源于软组织和骨骼的小圆细胞肿瘤，主要影响儿童和青少年。最不利的预后因素是诊断时存在远处转移。
对26例尤因肉瘤患者（14例男性，12例女性）的记录进行回顾性重新评估。
中位年龄为26.5（19 - 42）岁。8例患者（31%）原发肿瘤位于四肢，8例（31%）位于胸部，4例（15%）位于椎体，4例（15%）位于头颈部，2例（8%）位于腹部。5例患者（19%）诊断时存在远处转移。局限性疾病和转移性疾病的中位无进展生存期分别为72个月和10个月（p = 0.005）。转移性疾病的总生存期为19个月，局限性疾病的5年总生存率为64%（p = 0.006）。四肢患有局限性疾病且年龄小于30岁的患者预后良好。
尽管尤因肉瘤是一种影响儿童和青少年的肿瘤，但在成人中也可见，成人患者的预后通常较差。尽管它是一种高度恶性的肿瘤，但通过综合治疗有可能提高生存率。
